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Now showing items 16606-16625 of 24083
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Pharmacoeconomic evaluation and its application in clinical guideline development
(2018-08-11)Pharmacoeconomic evaluation is an analysis technique that combines data on both costs and health outcomes to allow clinical decision makers to assess the cost effectiveness of pharmaceutical products and services. It is ... -
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology
(2024-01-08)The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion ... -
Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica
(2002-09)The pharmacokinetics and pharmacodynamics of danofloxacin in calves with induced Mannheimia (Pasteurella) haemolytica pneumonia were evaluated. Calves received either saline as an intravenous (IV) bolus or danofloxacin ... -
Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats
(1997)Phenylbutazone was administered intravenously and orally to six goats as a single dose of 4.4 mg/kg and its disposition and bioavailability and the disposition of its active metabolite, oxyphenbutazone, in plasma were ... -
Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
(2012)The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and ... -
Pharmacokinetic features of the antiparasitic macrocyclic lactones
(2012-05)The macrocyclic lactones have pharmacokinetic properties which enhance their use against endo- and ectoparasites in animals and man. The most consistent physico-chemical feature of the group which contributes to their ... -
Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep
(1998-08)Flunixin meglumine (FM, 1.1 mg/kg) and phenylbutazone (PBZ, 4.4 mg/kg) were administered intravenously (i.v.) as a single dose to eight sheep prepared with subcutaneous (s.c.) tissue-cages in which an acute inflammatory ... -
Pharmacokinetic, biochemical and tolerance studies on carprofen in the horse
(1991-07)Carprofen, a non-steroidal anti-inflammatory drug (NSAID) was administered to three Thoroughbred geldings and three Shetland ponies to determine its plasma disposition and tolerance. The main pharmacokinetic characteristics ... -
Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine
(2004-12)The rise in incidence of antimicrobial resistance, consumer demands and improved understanding of antimicrobial action has encouraged international agencies to review the use of antimicrobial drugs. More detailed understanding ... -
Pharmacokinetics and applications of ampicillin sodium as an intravenous infusion in the horse
(1993-03)A regime for administration of ampicillin sodium by continuous intravenous infusions to horses was designed. The aim was to achieve plasma ampicillin concentrations between 5 and 10 micrograms/ml over a 4-h period. A 2 ... -
Pharmacokinetics and clinical effects in dogs of a sustained-release formulation of theophylline
(1993-08)Theophylline was administered orally in a sustained-release preparation at a dose rate of 20 mg/kg bodyweight to six beagle dogs. A mean (+/- se) maximum plasma concentration of 12.2 +/- 0.65 micrograms/ml was obtained ... -
Pharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dog
(1991-02)The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) were assessed in the dog. Cinchophen administered at a dose rate of 12-5 mg/kg intravenously had a volume of distribution (Vd area) of ... -
Pharmacokinetics and pharmacodynamics of piroxicam in dogs
(1991-06)Piroxicam was administered to beagle dogs intravenously and orally at a dose rate of 0.3 mg/kg bodyweight. It had an elimination half-life of 40.2 hours, a volume of distribution of 0.29 +/- 0.02 litres/kg and a body ... -
Pharmacokinetics and tissue disposition of danofloxacin in sheep
(1998-03)The plasma pharmacokinetics of danofloxacin administered at 1.25 mg kg(-1) body weight by the intravenous and intramuscular routes were determined in sheep. Tissue distribution was also determined following administration ... -
Pharmacokinetics and tolerance of florfenicol in Equidae
(1996-05)Florfenicol was administered to horses and ponies at a dose rate of 22 mg/kg bwt by i.v., i.m. and oral routes. Following i.v. administration it had an elimination half-life of 1.8 +/- 0.9 h, a body clearance of 0.4 +/- ... -
Pharmacokinetics of a porcine insulin zinc suspension in diabetic dogs
(1997-10)Ten dogs with naturally occurring diabetes mellitus were injected with a highly purified porcine insulin zinc suspension at a dose according to their expected requirement. Plasma insulin and glucose concentrations were ... -
Pharmacokinetics of acetylcholinesterase reactivator K203 and consequent evaluation of low molecular weight antioxidants/markers of oxidative stress
(2012)Oxime K203 is a new compound designed to be used as an acetylcholinesterase reactivator for the treatment of intoxication following exposure to tabun and certain pesticides. After intramuscular administration of a therapeutic ...