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Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons

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contributor authorShan, Dehong
contributor authorXie, Yongling
contributor authorRen, Guogang
contributor authorYang, Zhuo
date accessioned2017-12-12T17:07:03Z
date available2017-12-12T17:07:03Z
date issued2012-03-07
identifier citationShan , D , Xie , Y , Ren , G & Yang , Z 2012 , ' Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons ' Toxicology Letters , vol 209 , no. 2 , pp. 129-135 . DOI: 10.1016/j.toxlet.2011.12.001en
identifier issn0378-4274
identifier otherPURE: 12927328
identifier otherPURE UUID: 1d919c86-267e-4c3d-9564-22c6fa4d9f1a
identifier otherScopus: 84862812425
identifier otherPubMed: 22192952
identifier urihttp://hdl.handle.net/2299/19602
identifier urihttp://www.scopus.com/inward/record.url?scp=84862812425&partnerID=8YFLogxKen
description abstractThe effects of tungsten carbide nanoparticles (nano-WC) on the properties of voltage-dependent potassium currents and evoked action potentials were studied in the hippocampal CA1 pyramidal neurons of rats at the ages of postnatal days 10-14 using the whole-cell patch-clamp technique. The results indicated that: (1) the amplitudes of transient outward potassium current (I A) and delayed rectifier potassium current (I K) were significantly decreased by 10 -7g/ml nano-WC, while the current-voltage curves of I A and I K were significantly decreased by nano-WC from +10 to +90mV. (2) Nano-WC produced a depolarizing shift in the steady-state activation curve of I A and I K with increased slope factors, and delayed the recovery of I A from inactivation, but no significant effects were found on the inactivation of I A. (3) Nano-WC prolonged the evoked action potential duration and lowered the firing rate. These results suggest that 10 -7g/ml nano-WC can decrease the amplitudes of I A and I K currents by reducing the opening number of voltage-gated potassium channels and delaying the recovery of I A from inactivation, which indicate that nano-WC has the potential neurotoxicity.en
format extent7en
language isoeng
relation ispartofToxicology Lettersen
rightsen
subjectDelayed rectifier potassium currenten
subjectHippocampusen
subjectNeurotoxicityen
subjectTransient outward potassium currenten
subjectTungsten carbide nanoparticlesen
subjectToxicologyen
titleInhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neuronsen
typeArticleen
contributor institutionUniversity of Hertfordshireen
identifier doihttps://doi.org/10.1016/j.toxlet.2011.12.001
description statusPeer revieweden


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