Vesiclepedia : a compendium for extracellular vesicles with continuous community annotation
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Author
Kalra, Hina
Simpson, Richard J
Ji, Hong
Aikawa, Elena
Altevogt, Peter
Askenase, Philip
Bond, Vincent C
Borràs, Francesc E
Breakefield, Xandra
Budnik, Vivian
Buzas, Edit
Camussi, Giovanni
Clayton, Aled
Cocucci, Emanuele
Falcon-Perez, Juan M
Gabrielsson, Susanne
Gho, Yong Song
Gupta, Dwijendra
Harsha, H C
Hendrix, An
Hill, Andrew F
Inal, Jameel M
Jenster, Guido
Krämer-Albers, Eva-Maria
Lim, Sai Kiang
Llorente, Alicia
Lötvall, Jan
Marcilla, Antonio
Mincheva-Nilsson, Lucia
Nazarenko, Irina
Nieuwland, Rienk
Nolte-'t Hoen, Esther N M
Pandey, Akhilesh
Patel, Tushar
Piper, Melissa G
Pluchino, Stefano
Prasad, T S Keshava
Rajendran, Lawrence
Raposo, Graca
Record, Michel
Reid, Gavin E
Sánchez-Madrid, Francisco
Schiffelers, Raymond M
Siljander, Pia
Stensballe, Allan
Stoorvogel, Willem
Taylor, Douglas
Thery, Clotilde
Valadi, Hadi
van Balkom, Bas W M
Vázquez, Jesús
Vidal, Michel
Wauben, Marca H M
Yáñez-Mó, María
Zoeller, Margot
Mathivanan, Suresh
Attention
2299/20315
Abstract
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.