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dc.contributor.authorMeadows, H.J.
dc.contributor.authorBenham, C.D.
dc.contributor.authorCairns, W.
dc.contributor.authorGloger, I.
dc.contributor.authorJennings, C.
dc.contributor.authorMedhurst, A.D.
dc.contributor.authorMurdock, P.
dc.contributor.authorChapman, C.G.
dc.date.accessioned2009-06-08T08:52:39Z
dc.date.available2009-06-08T08:52:39Z
dc.date.issued2000
dc.identifier.citationMeadows , H J , Benham , C D , Cairns , W , Gloger , I , Jennings , C , Medhurst , A D , Murdock , P & Chapman , C G 2000 , ' Cloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channel ' , Pflugers Archiv European Journal of Physiology , vol. 439 , pp. 714-722 . https://doi.org/10.1007/s004240050997
dc.identifier.issn0031-6768
dc.identifier.otherPURE: 124759
dc.identifier.otherPURE UUID: ce9777e0-6d2b-49b2-aaf1-93ef347d6d47
dc.identifier.otherdspace: 2299/3504
dc.identifier.otherScopus: 0034109513
dc.identifier.urihttp://hdl.handle.net/2299/3504
dc.description“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s004240050997 [Full text of this article is not available in the UHRA]
dc.description.abstractWe have cloned human TREK-1, one of the newly emerging mammalian family of 2-P domain potassium channels. The channel has 411 amino acids with a 41-amino-acid extension at the C-terminus when compared with the cloned mouse TREK-1 channel. Expression of hTREK-1 produced a substantial hyperpolarising shift in resting membrane potential accompanied by the induction of large, outwardly rectifying, non-inactivating currents which were potassium selective. Pharmacologically, hTREK-1-mediated currents were only blocked to a limited extent by classic potassium channel blockers or open channel pore blockers known to potently inhibit other channels. The channel was reversibly potentiated by arachidonic acid. CNS distribution of hTREK-1 is widespread with higher levels being observed in caudate, putamen, amygdala, thalamus and spinal cord. Only low levels of expression were seen in the majority of peripheral regions. Thus, hTREK-1, although functionally and pharmacologically similar to mouse TREK-1, appears to have a more CNS-specific distribution.en
dc.language.isoeng
dc.relation.ispartofPflugers Archiv European Journal of Physiology
dc.titleCloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channelen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1007/s004240050997
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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