Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments
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Author
Traynor, M.J.
Brown, Marc
Pannala, A.
Beck, P.
Martin, G. P.
Attention
2299/3636
Abstract
Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram (R) ER tablets and T-long (R) capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural (TM) extended-release tablets in the presence of alcohol.