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Tissue transglutaminase (TG-2) modified amniotic membrane : a novel scaffold for biomedical applications
(2012-08)
The amniotic membrane (AM) is considered as a natural cell culture substrate and has occasionally been exploited in regenerative medicine especially for ocular surface reconstruction and dermal wound healing applications. ...
Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol
(2010-06)
The olive oil polyphenol, hydroxytyrosol (HT), is believed to be capable of exerting protection against oxidative kidney injury. In this study we have investigated the ability of HT and its O-methylated metabolite, ...
Glial metabolism of quercetin reduces its neurotoxic potential
(2008-10-15)
The neuroprotective effects of flavonoids will ultimately depend on their interaction with both neuronal and glial cells. In this study, we show that the potential neurotoxic effects of quercetin are modified by glial cell ...
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenols
(2008-08-15)
Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-c ...
Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis
(2008-01)
Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise for cardiac repair. However, poor viability of transplanted MSCs within the ischemic heart has limited their therapeutic potential. Our previous ...
Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette
(2008)
Mechanosensitivity in living biological tissue is a study area of increasing importance, but investigative tools are often inadequate. We have developed a noncontact nanoscale method to apply quantified positive and negative ...
Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
(2007-11)
There is growing interest in the potential beneficial effects of flavonoids in the aging and diseased brain. We have investigated the potential of the flavanone hesperetin and two of its metabolites, hesperetin-7-O-beta- ...
Antioxidant and free radical scavenging activity of isoflavone metabolites
(2003-09)
1. Soy isoflavones have been extensively studied because of their possible health-promoting effects. Genistein and daidzein, the major isoflavone aglycones, have received most attention; however, they undergo extensive ...