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Comparison of bioavailability and antiplatelet action of ticagrelor in patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction : A prospective, observational, single-centre study
(2017-10-12)
BACKGROUND: Data from available studies suggest that the presence of ST-elevation myocardial infarction (STEMI) may be associated with delayed and attenuated ticagrelor bioavailability and effect compared with non-ST-elevation ...
The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy
(2017-08-01)
There is an urgent need to develop new combination therapies beyond existing surgery, radio- and chemo-therapy, perhaps initially combining chemotherapy with the targeting specificities of immunotherapy. For this, strategies ...
Allopurinol as a therapeutic option in cardiovascular disease
(2017-04-01)
Epidemiological studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity also results in the formation of oxidative ...
Health Technology Assessment (HTA) Case Studies : Factors Influencing Divergent HTA Reimbursement Recommendations in Australia, Canada, England, and Scotland
(2017-03-31)
OBJECTIVES: To evaluate the national regulatory, health technology assessment (HTA), and reimbursement pathways for public health care in Australia, Canada, England, and Scotland, to compare initial Canadian national HTA ...
Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro
(2017-03-31)
Giardia intestinalis (G.I), is an anaerobic protozoan and the aetiological agent of giardiasis, a diarrhoea present worldwide and associated with poverty. G.I has a simple life cycle alternating between cyst and trophozoite. ...
A systematic review of the use of quality-of-life instruments in randomized controlled trials for psoriasis
(2017-03-16)
Planners of interventional studies in psoriasis face the dilemma of selecting suitable quality-of-life (QoL) measures. Systematic reviews have the potential of identifying psychometrically sound measures in a given therapeutic ...
Transferring patients home to die : what is the potential population in UK critical care units?
(BMJ Publishing Group, 2017-03-01)
OBJECTIVES: Most people when asked, express a preference to die at home, but little is known about whether this is an option for critically ill patients. A retrospective cohort study was undertaken to describe the size and ...
Sertraline Versus Placebo in Patients with Major Depressive Disorder Undergoing Hemodialysis : A Randomized, Controlled Feasibility Trial
(2017-02-07)
BACKGROUND AND OBJECTIVES: Depression is common in patients on hemodialysis, but data on the benefits and risks of antidepressants in this setting are limited. We conducted a multicenter, randomized, double-blind, ...
A single weekly Kt/Vurea target for peritoneal dialysis patients does not provide an equal dialysis dose for all
(2016-12-31)
Dialysis adequacy is traditionally based on urea clearance, adjusted for total body volume (Kt/Vurea), and clinical guidelines recommend a Kt/Vurea target for peritoneal dialysis. We wished to determine whether adjusting ...
Predicting Smartphone Operating System from Personality and Individual Differences
(2016-12-01)
Android and iPhone devices account for over 90 percent of all smartphones sold worldwide. Despite being very similar in functionality, current discourse and marketing campaigns suggest that key individual differences exist ...