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dc.contributor.authorIngram, R.J.
dc.contributor.authorBartlett, A
dc.contributor.authorBrown, Marc
dc.contributor.authorMarriott, C.
dc.contributor.authorWhitfield, P.J.
dc.date.accessioned2007-10-11T15:56:31Z
dc.date.available2007-10-11T15:56:31Z
dc.date.issued2003
dc.identifier.citationIngram , R J , Bartlett , A , Brown , M , Marriott , C & Whitfield , P J 2003 , ' Penetration of human skin by the cercariae of Schistosoma mansoni : an investigation of the effect of multiple cercarial applications ' , Journal of Helminthology , vol. 77 , no. 1 , pp. 27-31 . https://doi.org/10.1079/JOH2002157
dc.identifier.issn0022-149X
dc.identifier.otherPURE: 183724
dc.identifier.otherPURE UUID: ab7194ae-4ff0-47c8-8794-c99a12cd43c0
dc.identifier.otherdspace: 2299/902
dc.identifier.otherWOS: 000181019300006
dc.identifier.otherScopus: 0037341023
dc.identifier.urihttp://hdl.handle.net/2299/902
dc.description.abstractIt has previously been postulated that L-arginine emitted by penetrating Schistosoma mansoni cercariae serves as an intraspecific signal guiding other cercariae to the penetration site. It was suggested that penetrating in groups offers a selective advantage. If this hypothesis is correct and group penetration at one site on the host offers an advantage, it would follow that at such a site, successive groups of cercariae would be able to penetrate skin in either greater numbers or at a faster rate. This prediction was tested by the use of an in vitro model of cercarial penetration based on the Franz cell and using human skin. It was demonstrated that there was no increase in the percentage of cercariae able to penetrate the skin with subsequent exposures. Consequently, it seems unlikely that the release of L-arginine by cercariae during penetration could have evolved as a specific orientation system based on a selective advantage offered by group penetration.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofJournal of Helminthology
dc.subjectCHEMICAL STIMULI
dc.subjectMIGRATION
dc.titlePenetration of human skin by the cercariae of Schistosoma mansoni : an investigation of the effect of multiple cercarial applicationsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1079/JOH2002157
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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