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Browsing by Author "Vafeiadou, Katerina"
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Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
Vauzour, David; Vafeiadou, Katerina; Rice-Evans, Catherine; Williams, Robert J.; Spencer, Jeremy P. E. (2007-11)There is growing interest in the potential beneficial effects of flavonoids in the aging and diseased brain. We have investigated the potential of the flavanone hesperetin and two of its metabolites, hesperetin-7-O-beta- ... -
Are dietary fatty acid intakes associated with arterial stiffness and blood pressure?
Weech, Michelle; Vafeiadou, Katerina; Mihaylova, Rada; Hobby, Emma; Yaqoob, Parveen; Todd, Sue; Jackson, Kim G.; Lovegrove, Julie A. (2011-01)CVD is the major cause of death in Western societies. Arterial stiffness is a key factor in cardiovascular physiology, reflecting the alterations to the mechanical properties of the blood vessels(1). It can be measured ... -
The beneficial effects of dietary flavonoids : sources, bioavailability and biological functions
Spencer, Jeremy P. E.; Vauzour, David; Vafeiadou, Katerina; Rodriguez-Mateos, Ana (CAB International, 2008) -
Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury
Vauzour, David; Vafeiadou, Katerina; Corona, Giulia; Pollard, Susan E.; Tzounis, Xenofon; Spencer, Jeremy P. E. (2007-04-18)White wines are generally low in polyphenol content as compared to red wines. However, Champagne wines have been shown to contain relatively high amounts of phenolic acids that may exert protective cellular actions in vivo. ... -
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
Vafeiadou, Katerina; Vauzour, David; Lee, Hung Yi; Rodriguez-Mateos, Ana; Williams, Robert J.; Spencer, Jeremy P. E. (2009-04-01)Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) ... -
Consumption of soy isoflavones does not affect plasma total homocysteine or asymmetric dimethylarginine concentrations in healthy postmenopausal women
Reimann, Manja; Dierkes, Jutta; Carlsohn, Anja; Talbot, Duncan; Ferrari, Marika; Hallund, Jesper; Hall, Wendy L; Vafeiadou, Katerina; Huebner, Ulrich; Branca, Francesco; Bugel, Susanne; Williams, Christine M; Zunft, H-J Franz; Koebnick, Corinna (2006-01)Postmenopausal women are at increased risk for cardiovascular disease because many risk factors are aggravated by menopause. Phytoestrogens may modulate risk factors favorably, involving mechanisms similar to estrogen. The ... -
Development of a Food-Exchange Model to Replace Saturated Fat with MUFAs and n-6 PUFAs in Adults at Moderate Cardiovascular Risk
Weech, Michelle; Vafeiadou, Katerina; Hasaj, Marinela; Todd, Susan; Yaqoob, Parveen; Jackson, Kim G.; Lovegrove, Julie A. (2014-06-01)The recommendation to reduce saturated fatty acid (SFA) consumption to ≤10% of total energy (%TE) is a key public health target aimed at lowering cardiovascular disease (CVD) risk. Replacement of SFA with unsaturated fats ... -
Dietary flavonoids as neuroprotective agents
Spencer, Jeremy P. E.; Vauzour, David; Vafeiadou, Katerina; Rodriguez Mateos, Ana (CRC Press, London, UK., 2010) -
Does genotype and equol-production status affect response to isoflavones? : Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women
Vafeiadou, Katerina; Hall, Wendy L.; Williams, Christine M. (2006-02)The increase in CVD incidence following the menopause is associated with oestrogen loss. Dietary isoflavones are thought to be cardioprotective via their oestrogenic and oestrogen receptor-independent effects, but evidence ... -
Final evidence report as part of preparatory work for the setting of Dietary Reference Values for magnesium, copper, and phosphorus
Lewis, Kathleen; Madden, Angela; Tammam, Jonathan; Tzilivakis, John; Vafeiadou, Katerina (European Food Safety Authority (EFSA), 2014-11-04)As part of its mandate from the European Commission, EFSA must review existing advice from the Scientific Committee for Food (SCF) on Dietary Reference Values (DRVs) for energy, macro- and micronutrients and other substances ... -
Final evidence report as part of preparatory work for the setting of Dietary Reference Values for sodium and chloride
Lewis, Kathleen; Madden, Angela; Tammam, Jonathan; Tzilivakis, John; Vafeiadou, Katerina (European Food Safety Authority (EFSA), 2014-11-04) -
Flavonoids and Neuroinflammation
Vauzour, David; Vafeiadou, Katerina (CRC Press, London, UK., 2012-05) -
Glial metabolism of quercetin reduces its neurotoxic potential
Vafeiadou, Katerina; Vauzour, David; Rodriguez-Mateos, Ana; Whiteman, Matthew; Williams, Robert J.; Spencer, Jeremy P. E. (2008-10-15)The neuroprotective effects of flavonoids will ultimately depend on their interaction with both neuronal and glial cells. In this study, we show that the potential neurotoxic effects of quercetin are modified by glial cell ... -
Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway
Vauzour, David; Vafeiadou, Katerina; Rice-Evans, Catherine; Cadenas, Enrique; Spencer, Jeremy P. E. (2007-12-15)The cellular actions of genistein, and its in vivo metabolites, are believed to mediate the decreased risk of breast cancer associated with high soy consumption. The genistein metabolite, 5,7,3',4'-tetrahydroxyisoflavone ... -
Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols
Vauzour, David; Vafeiadou, Katerina; Spencer, Jeremy P. E. (2007-10-19)The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, ... -
Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol
Incani, Alessandra; Deiana, Monica; Corona, Giulia; Vafeiadou, Katerina; Vauzour, David; Dessì, M. Assunta; Spencer, Jeremy P. E. (2010-06)The olive oil polyphenol, hydroxytyrosol (HT), is believed to be capable of exerting protection against oxidative kidney injury. In this study we have investigated the ability of HT and its O-methylated metabolite, ... -
Isoflavones and coronary heart disease
Hall, Wendy L; Vafeiadou, Katerina; Minihane, Anne-Marie; Rimbach, Gerald; Williams, Christine M (Woodhead Publishing, Cambridge, UK., 2004) -
Low-grade inflammation, diet composition and health : current research evidence and its translation
Minihane, Anne-Marie; Vinoy, Sophie; Russell, Wendy R.; Baka, Athanasia; Roche, Helen M.; Tuohy, Kieran M.; Teeling, Jessica L.; Blaak, Ellen E.; Fenech, Michael; Vauzour, David; McArdle, Harry J.; Kremer, Bas H. A.; Sterkman, Luc; Vafeiadou, Katerina; Benedetti, Massimo Massi; Williams, Christine M.; Calder, Philip C. (2015-10-14)The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease ... -
Modulation of Neuroinflammation by Dietary Flavonoids
Vauzour, David; Spilsbury, Alison; Vafeiadou, Katerina; Rattray, Marcus; Spencer, Jeremy P E (Nova Science Publishers Inc., USA., 2012-11-30)There is increasing evidence to suggest neuroinflammatory processes contribute to the cascade of events that lead to the progressive neuronal damage observed in neurodegenerative disorders such as Parkinson‘s disease and ... -
Neuroinflammation : modulation by flavonoids and mechanisms of action
Spencer, Jeremy P. E.; Vafeiadou, Katerina; Williams, Robert J.; Vauzour, David (2012-02)Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease. Recently, there has ...