Browsing by Author "Inal, Jameel"

Now showing items 21-31 of 31

    • Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines 

      Inal, Jameel (2018-11-23)
      The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of ...

    • A new landscape of host–protozoa interactions involving the extracellular vesicles world 

      Gavinho, Bruno; Rossi, Izadora; Evans-Osses, Ingrid; Inal, Jameel; Ramirez, Marcel Ivan (2018-10-01)
      Extracellular vesicles (EVs) are released by a wide number of cells including blood cells, immune system cells, tumour cells, adult and embryonic stem cells. EVs are a heterogeneous group of vesicles (~30–1000 nm) including ...

    • Peptidylarginine deiminase inhibitors reduce bacterial membrane vesicle release and sensitize bacteria to antibiotic treatment 

      Kosgodage, Uchini S; Matewele, Paul; Mastroianni, Giulia; Lange, Sigrun; Kraev, Igor; Brotherton, Dominik; Awamaria, Brigitte; Nicholas, Anthony P.; Inal, Jameel (2019-06-27)
      Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically ...

    • Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines 

      Uysal-Onganer, Pinar; MacLatchy, Amy; Mahmoud, Rayan; Kraev, Igor; Thompson, Paul R; Inal, Jameel; Lange, Sigrun (2020-02-22)
      Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis. Roles for peptidylarginine deiminases (PADs) in GBM have recently been highlighted. Here, two GBM cell lines were treated with PAD2, ...

    • Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme 

      Kosgodage, Uchini S; Uysal-Onganer, Pinar; MacLatchy, Amy; Kraev, Igor; Chatterton, Nicholas; Nicholas, Anthony P.; Inal, Jameel; Lange, Sigrun (2018-12-28)
      Glioblastoma multiforme (GBM) is the most aggressive form of adult primary malignant brain tumour with poor prognosis. Extracellular vesicles (EVs) are a key-mediator through which GBM cells promote a pro-oncogenic ...

    • Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets 

      Antwi-Baffour, Samuel; Malibha-Pinchbeck, Memory; Stratton, Dan; Jorfi, Samireh; Lange, Sigrun; Inal, Jameel (2019-12-18)
      This study sought to measure medium-sized extracellular vesicles (mEVs) in plasma, when patients have low Plasmodium falciparum early in infection. We aimed to define the relationship between plasma mEVs and: (i) parasitaemia, ...

    • Proceedings of Abstracts, School of Physics, Engineering and Computer Science Research Conference 2022 

      Amafabia, Daerefa-a; Asimea, Laurel; Bally, John; Baran, Anthony; Boies, Adam; Borjali, Amirhossein; Bosomworth, Chloe; Burningham, Ben; Chaliasou, Napoleana-Anna; CHEN, Yong Kang; Cheong, Yuen Ki; Chizari, Mahmoud; Chung, Etelka; Coppin, Kristen; David-West, Opukuro; Dennler, Nik; Dhakal, Hom; Dimov, Nikolay; Dmitruk, Emil; Donald, Allen; Drix, Damien; Dzib, Sergio A.; Eltaweel, Mahmoud; Fadlelseed, Sajid; Farahani, Atena; Felix, Adrian; Foat, Tim; Forbrich, Jan; Franco, Maximilien; Gaarn, Joesphine; Garratt, Tracy; Geach, Jim; Ghias, Narges; Ghita, Adrian; Giannetti, Niccolo; Vargas-Gonzalez, Jaime; Greenaway, Richard; Haritos, George; Hatami, Sara; Haydock, David; Helian, Na; Herfatmanesh, Mohammad Reza; Herve, Jean-Baptiste; Hesse, Evelyn; Korani, Hossein; Hosseini, Vahid; Hu, Wei; Hubbard, Thomas; Inal, Jameel; Irigo, Patrick; Ismail, Sikiru O.; Jepleting, Fiona; Ji, Wei; Johnston, Ian; Jombo, Gbanaibolou; Kadir, Shabnam; Kalyvas, Christos; Kamran, Syed Muhammad; Kanellopoulos, Antonios; Kiflay, Aklil Zenebe; Kirner, Raimund; Knox, Kerry; Kobayashi, Chiaki; Kumar, Dhirendra; Kumar, Ritesh; Lane, Peter; Lekkala, Himayasri; Lewis, Andrew; Li, Liang; Luo, Qi; Madani, Hossein; Mallet, Colin; Maruthupandian, Surya; Mathen, Elizabeth Reeja; Matousek, Pavel; McCool, Simon; McGarry, James C.; Menon, Catherine; Metzner, Christoph; Miles, Rachael E. H.; Moeinnia, Hadi; Moggridge, Paul; Mohseni, Mahdi; Montalvão, Diogo; Moraby, Mohammad Najeeb; Murnane, Darragh; Norgate, Marc; Nourani, Amir; Prasad, Kumar Shantanu; Ramalingam, Soodamani; Rastogi, Shavika; Reid, Jonathan P.; Ren, Guogang; Rivilla, Victor M.; Saidpour, Hossein; Saito, Kiyoshi; Sajedi, Seyed Amir Hossein; Salge, Christoph; Samararatne, Samadhi; Schmuker, Michael; Sensoy, Elif; Shriram, Ajay; Singh, Harpreet; Sorouraddin, Yasser; Steuber, Volker; Stone, Nicholas; Sun, Yi; Sureddi, Roopesh; Sutton, Samuel; Thomas, Peter; Timms, Andrew R; Tiwari, P. R.; Tsokanos, Athanasios; Vadalia, Mansukhlal; Yaqoob, Muhammad; Yulianto, Muhamad; Zheng, Minghua (University of Hertfordshire, 2022-11-04)
      The present proceedings record the abstracts submitted and accepted for presentation at SPECS 2022, the second edition of the School of Physics, Engineering and Computer Science Research Conference that took place online, ...

    • Prostate cancer and microfluids 

      Bernstein, D E; Piedad, J; West, A; Johnston, Ian; Dimov, Nikolay; Inal, Jameel; Vasdev, Nikhil; Hemsworth, L (2021-08-30)
      Microfluidic systems aim to detect sample matter quickly with high sensitivity and resolution, on a small scale. With its increased use in medicine, the field is showing significant promise in prostate cancer diagnosis and ...

    • Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles 

      Stratton, Dan; Moore, Colin; Zheng, Lei; Lange, Sigrun; Inal, Jameel (2015-05-08)
      MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release through PKC, ...

    • Therapeutic use of calpeptin in COVID-19 infection 

      Inal, Jameel; Paizuldaeva, Ainura; Terziu, Esmeralda (2022-10-28)
      This perspective considers the benefits of the potential future use of the cell permeant calpain inhibitor, calpeptin, as a drug to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent work ...

    • Treatment of Prostate Cancer Using Deimination Antagonists and Microvesicle Technology. 

      Lange, Sigrun; Kholia, Sharad; Kosgodage, Uchini S; Inal, Jameel (Springer Nature, 2017)
      Cellular microvesicle (MV) release, which occurs in most eukaryotic cells, is also involved in cancer progression and has recently been associated with peptidylarginine deiminase (PAD)-driven protein deimination. Evidence ...