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Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats
Ali, B.H.; Cheng, Z.; Hadrami, G.; Bashir, A.K.; McKellar, Quintin (1996-06)Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 +/- 1.4 ml/mL . kg vs, 52.8 +/- ... -
Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs
Gokbulut, C.; Bilgili, A.; Hanedan, B.; McKellar, Quintin (2007)The plasma disposition of fenbendazole (FBZ), oxfendazole (OFZ) and albendazole (ABZ); and the enantiospecific disposition of OFZ, and ABZSO produced were investigated following an oral administration (50 mg/kg) in dogs. ... -
Comparative plasma disposition, bioavailability and efficacy of ivermectin following oral and pour-on administrations in horses
Gokbulut, C.; Cirak, V. Y.; Senlik, B.; Aksit, D.; Durmaz, M.; McKellar, Quintin (2010)Pour-on formulations of endectocides decrease the risk of injury for both user and animal, and are particularly convenient for animal owners who can apply the product. This study was designed to investigate the plasma ... -
Comparative plasma dispositions of ivermectin and doramectin following subcutaneous and oral administration in dogs
Gokbulut, C.; Karademir, U.; Boyacioglu, M.; McKellar, Quintin (2006)This study evaluates the comparative plasma dispositions of ivermectin (IVM) and doramectin (DRM) following oral and subcutaneous administration (200 μg/kg) over a 40-day period in dogs. Twenty bitches were allocated by ... -
Comparison of four methods for the determination of plasma pepsinogen concentration
Scott, I.; Stear, M.J.; McKellar, Quintin (1995-11)Four methods for estimating plasma pepsinogen concentrations were compared to determine the most suitable for routine use. Three of the methods were colorimetric assays which used glycine-buffered albumin, albumin, or ... -
Comparison of ivermectin, oxfendazole and levamisole for use as anthelmintics during the periparturient period in sheep
McKellar, Quintin; Marriner, S.; Bogan, J. (1988)Ewes synchronised with progestin impregnated sponges to reduce the spread of lambing were treated during the periparturient period with anthelmintic. The suppression of nematode egg output in faeces was measured in ewes ... -
Comparison of pepsinogen forms in cattle, sheep and goats
Mostofa, M.; McKellar, Quintin; Eckersall, P. D. (1990)Different types and subtypes of pepsinogen extracted from bovine, ovine and caprine abomasa were found to differ according to their phosphate content and relative molecular mass (Mr). Bovine pepsinogens had organic phosphate ... -
Comparison of the anthelmintic efficacy of oxfendazole or ivermectin administered orally and ivermectin administered subcutaneously to sheep during the periparturient period
McKellar, Quintin; Marriner, S. E. (1987)The suppression of nematode egg output in faeces was measured in ewes treated just before lambing with either oxfendazole or ivermectin by oral drench or with ivermectin by subcutaneous injection. Ivermectin and oxfendazole ... -
Comparison of two techniques used for the recovery of nematode infective larvae from pasture
Gettinby, G.; McKellar, Quintin; Bairden, K.; Theodoridis, Y.; Whitelaw, A. (1985)The recovery of gastrointestinal nematode infective larvae from herbage collected manually was compared with the recovery from herbage ingested by sheep with oesophageal fistulae, on five occasions during the grazing season. ... -
Current models in pharmacokinetics : applications in veterinary pharmacology
Kinabo, L. D.; McKellar, Quintin (1989)Major advances in developing models for pharmacokinetic studies have been made in recent years, and different approaches can now be employed. These include the use of (1) compartmental models, (2) non-compartmental models, ... -
Cytokine mRNA expression in cattle infected with different dosages of Mycobacterium bovis
Boddu-Jasmine, H.C.; Witchell, J.; Vordermeier, M.; Wangoo, A.; Goyal, M. (2008)Cytokine mRNA expression of pro-inflammatory cytokines, i.e., interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α) and anti-inflammatory cytokines, i.e., interleukin-4 (IL-4), interleukin-10 (IL-10) was quantified ... -
Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
Determination of halofuginone in bovine plasma by competing-ion high performance liquid chromatography after solid phase extraction
Kinabo, L. D.; McKellar, Quintin; Murray, M. (1989)A high performance liquid chromatography (HPLC) method for the determination of the anticoccidial and antitheilerial drug halofuginone in bovine plasma was developed. Samples were diluted with acetic acid (10%, v/v) and ... -
Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography
Benchaoui, H. A.; McKellar, Quintin (1993)A high performance liquid chromatographic method has been developed for the determination of rafoxanide and closantel in ovine plasma. Acetonitrile and chloroform were used for the extraction. The mean recoveries were ... -
Determination of short-chain fatty acids in equine caecal liquor by ion exchange high performance liquid chromatography after solid phase extraction
Horspool, L. J.; McKellar, Quintin (1991-09)A high performance liquid chromatography (HPLC) method was developed for the determination of seven short-chain fatty acids in equine caecal liquor. Samples were cleaned up on a Sep-pak (C18) cartridge, and the analyte was ... -
Dexamethasone decreases plasma levels of the prochiral fenbendazole and its chiral and achiral metabolites in sheep
Sanchez, S.; Small, J.; Jones, D.G.; McKellar, Quintin (2003-07)1. The effect of co-administration of either short- or long-acting formulations of DXM on hepatic function and the plasma pharmacokinetic behaviour of prochiral fenbendazole (FBZ) and its metabolites was evaluated in sheep. ... -
Diagnostic value of gastrin for clinical bovine ostertagiosis
Hilderson, H.; Vercruysse, J.; Berghen, P.; Dorny, P.; McKellar, Quintin (1992)Gastrin values were evaluated in 130 parasite naive calves, in 61 first season grazing calves during six field trials and in 8 experimentally infected adult immune cows. The gastrin values were linked to pepsinogen levels ... -
Different patterns of faecal egg output following infection of Scottish blackface lambs with Ostertagia circumcincta
Stear, M. J.; Bairden, K.; Bishop, S. C.; Duncan, J. L.; Karimi, S. K.; McKellar, Quintin; Murray, M. (1995-08)Faecal nematode egg counts were monitored in 184 Scottish Blackface lambs during natural exposure to a mixed, predominantly Ostertagia circumcincta infection and 12 lambs were selected which showed consistently zero (low ... -
Disposition of ampicillin sodium in horses, ponies and donkeys after intravenous administration
Horspool, L. J.; Sarasola, P.; McKellar, Quintin (1992-02) -
Disposition of oxytetracycline in horses, ponies and donkeys after intravenous administration
Horspool, L. J.; McKellar, Quintin (1990-07)