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Now showing items 11013-11032 of 24073
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In Vitro Cell Models for Ophthalmic Drug Development Applications
(2016-04-20)Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the ... -
The in vitro efficacy of haemostatic products in the presence of chemical warfare agents-Sulphur mustard (HD) and VX
(2009-07-28)Haemorrhage remains to be a leading cause of death for trauma victims (Bellamy, 1984). Wound contamination poses an additional complication in the initial management of haemorrhaging wounds, with no specific medical treatment ... -
In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails
(2018-09)Background: Topical antifungal treatments for onychomycosis are applied to clean, unpolished nails for 48 weeks or longer. Patients often wish to mask their infection with nail polish yet there is no evidence to suggest ... -
An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs
(2001-08-28)Recently, Solaraze gel (Bioglan, Herts, UK) a topical hyaluronan (HA)/dictofenac formulation for the treatment of actinic keratosis has received regulatory approval in the US, Canada and Europe for the treatment of actinic ... -
An in vitro investigation of the mode of action of hyaluronan as a drug delivery vehicle using circular dichroism
(Royal Society of Medicine Press, 1995) -
In vitro mutation and selection of doubled-haploid Brassica napus lines with improved resistance to Sclerotinia sclerotiorum
(2005-06)This paper describes a new protocol to develop doubled-haploid (DH) Brassica napus lines with improved resistance to Sclerotinia sclerotiorum. In this protocol, haploid seedlings derived from microspore cultures of B. napus ... -
In vitro recognition of a 190 kda putative attachment receptor from the cuticle of Meloidogyne javanica by Pasteuria penetrans spore extract
(1994)Studies were undertaken to develop an improved understanding of the mechanism by which spores of Pasteuria penetrans bind to the cuticle of susceptible nematode hosts. A polyclonal antibody recognized an antigenic ladder ... -
In vitro recording of mesenteric afferent nerve activity in jejunal and colonic segments from rodents
(2016-10-25)Afferent nerves not only convey information concerning normal physiology, but also signal disturbed homeostasis and pathophysiological processes of the different organ systems from the periphery towards the central nervous ... -
In vitro skin absorption and decontamination of sulphur mustard : Comparison of human and pig-ear skin
(2001)The aim of this study was to evaluate the use of an in vitro skin diffusion cell system as a model for assessing decontaminants against the chemical warfare agent sulphur mustard (SM). The in vitro absorption rates of SM ... -
In vitro studies of siderophore production by wild type and rifampicin resistant strains of fluorescent Pseudomonads
(1989-05)Wild type (Rif−) and rifampicin resistant (Rif+) isolates of fluorescent Pseudomonads were grown in King’s B liquid medium in the presence and absence of iron and subcultured every 48 h for 12 days. Growth rates and the ... -
An in vitro study of the diclofenac delivery properties of hyaluronan in human skin
(1999)Previous in vitro studies have indicated that hyaluronan, when compared to buffer controls, effects a controlled and sustained release of diclofenac through the skin by the formation of a reservoir of the drug around the ... -
In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents
(2008)The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Nano particles of CuO had ... -
In vitro susceptibility of Clostridium difficile to SMT19969 and comparators, as well as the killing kinetics and post-antibiotic effects of SMT19969 and comparators against C. difficile
(2015-06-01)OBJECTIVES: SMT19969 is a novel antimicrobial under clinical development for the treatment of Clostridium difficile infection (CDI). The objective was to determine the comparative susceptibility of 82 C. difficile clinical ... -
In vitro susceptibility of genotypically distinct and clonal Clostridium difficile strains to oritavancin
(2008)Clostridium difficile infection is a nosocomial disease of increasing importance. First-line treatment is limited to metronidazole or vancomycin. Oritavancin is a lipoglycopeptide with activity against Gram-positive bacteria, ... -
In vitro synthesis of minus-strand RNA by an isolated cereal yellow dwarf virus RNA-dependent RNA polymerase requires VPg and a stem-loop structure at the 3' end of the virus RNA
(2006-11)Cereal yellow dwarf virus (CYDV) RNA has a 5'-terminal genome-linked protein (VPg). We have expressed the VPg region of the CYDV genome in bacteria and used the purified protein (bVPg) to raise an antiserum which was able ... -
In vitro synthesized RNA generated from cDNA clones of both genomic components of Cucurbit yellow stunting disorder virus replicates in cucumber protoplasts.
(2016-06-14)Cucurbit yellow stunting disorder virus (CYSDV), a bipartite whitefly-transmitted virus, constitutes a major threat to commercial cucurbit production worldwide. Here, construction of full-length CYSDV RNA1 and RNA2 cDNA ... -
An in vitro technique for evaluating inhaled nasal delivery systems
(2002)This report describes a novel technique for delivering aerosols to the surface of respiratory epithelial cells cultured tit an air-liquid interface. A model microsphere formulation for nasal delivery was aerosolised using ...