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Now showing items 11379-11398 of 24056
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Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway
(2007-12-15)The cellular actions of genistein, and its in vivo metabolites, are believed to mediate the decreased risk of breast cancer associated with high soy consumption. The genistein metabolite, 5,7,3',4'-tetrahydroxyisoflavone ... -
Inhibition of cyclo-oxygenase-2 expression by resveratrol derivatives from peanuts (Arachis hypogea L.)
(2004)A wide variety of plant phenolic substances possess anti-inflammatory and anti-carcinogenic activities, and for many of these substances inhibition of cyclo-oxygenase-2 (COX-2) appears to be an important mechanism of action ... -
Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory drugs with nitroxy moiety
(1996)Effects of novel nitric oxide-releasing nonsteroidal anti-inflammatory compounds (NONSAIDs) on induction of nitric oxide (NO) synthase by bacterial lipopolysaccharide (LPS) were examined in a cultured murine macrophage ... -
Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo
(2015-08-25)Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could ... -
Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells
(1998)We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 ... -
Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols
(2007-10-19)The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, ... -
Inhibition of the glycaemic response by onion : a comparison between lactose-tolerant and lactose-intolerant adults
(2016-03-30)This pilot study compared inhibition of the glycaemic response to glucose by a dietary source of quercetin glucosides (onion) in lactose-tolerant adults (n = 12) and lactose-intolerant adults (n = 12). We hypothesised that ... -
Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?
(2010)Background: Obsessive-compulsive disorder (OCD) has been associated with impairments in stop-signal inhibition, a measure of motor response suppression. The study used a novel paradigm to examine both thought suppression ... -
Inhibition or Treatment of Dyskinesia
(2006-08-24)Prevention or treatment of dyskinesia induced by L-dopa or dopamine agonist can be effected by use of a selective inhibitor of neuronal nitric oxide synthase -
Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder
(2020-02)BACKGROUND: Obsessive-compulsive disorder (OCD) is a prevalent neuropsychiatric condition, with biological models implicating disruption of cortically mediated inhibitory control pathways, ordinarily serving to regulate ... -
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates
(2004-02-23)Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by ... -
The inhibitory effect of 6-gingerol and cisplatin on ovarian cancer and antitumor activity: In silico, in vitro, and in vivo
(2023-03-03)Background: Epithelial ovarian cancer is very common in women and causes hundreds of deaths per year worldwide. Chemotherapy drugs including cisplatin have adverse effects on patients’ health. Complementary treatments and ... -
Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons
(2012-03-07)The effects of tungsten carbide nanoparticles (nano-WC) on the properties of voltage-dependent potassium currents and evoked action potentials were studied in the hippocampal CA1 pyramidal neurons of rats at the ages of ... -
The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons
(2011-10)The application of the nano-sized materials continues to grow at a rapid rate in the fields of medicine, biotechnology, and environmental technology. Voltage-gated potassium currents play a key role in excitable cellular ... -
Inhibitory Synaptic Plasticity and Gain Modulation in Cerebellar Nucleus Neurons
(2016-05-17)Neurons can encode information using the rate of their action potentials, making the relation between input rate and output rate a prominent feature of neuronal information processing. This relation, known as I-O function, ... -
Inhomogeneous Enrichment of Radioactive Nuclei in the Galaxy: Deposition of Live 53 Mn, 60 Fe, 182 Hf, and 244 Pu into Deep-sea Archives. Surfing the Wave?
(2023-02-16)While modeling the galactic chemical evolution (GCE) of stable elements provides insights to the formation history of the Galaxy and the relative contributions of nucleosynthesis sites, modeling the evolution of short-lived ...