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Browsing by Author "Arillotta, Davide"
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Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals
Schifano, Fabrizio; Catalani, Valeria; Sharif, Safia (Sophia); Napoletano, Flavia; Corkery, John; Arillotta, Davide; Fergus, Suzanne; Vento, Alessandro; Guirguis, Amira (2022-04-02)‘Smart drugs’ (also known as ‘nootropics’ and ‘cognitive enhancers’ [CEs]) are being used by healthy subjects (i.e. students and workers) typically to improve memory, attention, learning, executive functions and vigilance, ... -
Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Corkery, John M; Stair, Jacqueline L; Schifano, Fabrizio; Guirguis, Amira (2024-01-12)Introduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around ... -
The clinical challenges of synthetic cathinones
Schifano, Fabrizio; Napoletano, Flavia; Arillotta, Davide; Zangani, Caroline; Gilgar, Liam; Guirguis, Amira; Corkery, John; Vento, Alessandro (2019-11-01)Within the new psychoactive substances (NPS) scenario, several hundreds of different molecules, mostly including synthetic cannabinoids and cathinones, have so far been identified. The aims of the paper were to: (a) identify ... -
Covid-19 pandemic impact on substance misuse: a social media listening, mixed method analysis.
Arillotta, Davide; Guirguis, Amira; Corkery, John Martin; Scherbaum, Norbert; Schifano, Fabrizio (2021-07-09)The restrictive measures adopted during the COVID-19 pandemic modified some previously consolidated drug use patterns. A focus on social networks allowed drug users to discuss, share opinions and provide advice during a ... -
The e-psychonauts’ ‘Spiced’ World; assessment of the synthetic cannabinoids’ information available online
Zangani, Caroline; Schifano, Fabrizio; Napoletano, Flavia; Arillotta, Davide; Gilgar, Liam; Guirguis, Amira; Corkery, John Martin; Gambini, Orsola; Vento, Alessandro (2020-03-02)Background: A wide range of novel psychoactive substances (NPS) is regularly searched and discussed online by web-based drug enthusiasts (i.e. the e-psychonauts). Among NPS, the range of synthetic cannabinoids (SC; ‘Spice’) ... -
Exploring the Association Between Suicidal Thoughts, Self-Injury, and GLP-1 Receptor Agonists in Weight Loss Treatments: Insights from Pharmacovigilance Measures and Unmasking Analysis
Guirguis, Amira; Chiappini, Stephania; Papanti, P G Duccio; Vickers-Smith, Rachel; Harris, Daniel; Corkery, John; Arillotta, Davide; Floresta, Giuseppe; Martinotti, Giovanni; Schifano, Fabrizio (2024-05)Introduction: The study addresses concerns about potential psychiatric side effects of Glucagon-like peptide-1 receptor agonists (GLP-1 RA). Aim: The aim of this work was to analyse adverse drug reports (ADRs) from the ... -
Exploring the Potential Impact of GLP-1 Receptor Agonists on Substance Use, Compulsive Behavior, and Libido: Insights from Social Media Using a Mixed-Methods Approach
Arillotta, Davide; Floresta, Giuseppe; Papanti Pelletier, G. Duccio; Guirguis, Amira; Corkery, John Martin; Martinotti, Giovanni; Schifano, Fabrizio (2024-06-20)Glucagon-like peptide-1 (GLP-1) is involved in a range of central and peripheral pathways related to appetitive behavior. Hence, this study explored the effects of glucagon-like peptide-1 receptor ag-onists (GLP-1 RAs) on ... -
GLP-1 Receptor Agonists and Related Mental Health Issues; Insights from a Range of Social Media Platforms Using a Mixed-Methods Approach
Arillotta, Davide; Floresta, Giuseppe; Guirguis, Amira; Corkery, John Martin; Catalani, Valeria; Martinotti, Giovanni; Sensi, Stefano L.; Schifano, Fabrizio (2023-10-24)The emergence of glucagon-like peptide-1 receptor agonists (GLP-1 RAs; semaglutide and others) now promises effective, non-invasive treatment of obesity for individuals with and without diabetes. Social media platforms’ ... -
Identifying new/emerging psychoactive substances at the time of COVID-19; a web-based approach
Catalini, Valeria; Arillotta, Davide; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Schifano, Fabrizio (2021-02-09)COVID-19-related disruptions of people and goods' circulation can affect drug markets, especially for new psychoactive substances (NPSs). Drug shortages could cause a change in available NPS, with the introduction of new, ... -
New Psychoactive Substances (NPS) and Serotonin Syndrome onset: a Systematic Review
Schifano, Fabrizio; Chiappini, Stephania; Corkery, John; Scherbaum, Norbert; Napoletano, Flavia; Arillotta, Davide; Catalani, Valeria; Vento, Alessandro; Pettorruso, Mauro; Martinotti, Giovanni; di Giannantonio, Massimo; Guirguis, Amira (2021-05-01)The use of several new psychoactive substances (NPS) has become very popular and is posing global health risks. Chemically and pharmacologically diverse molecules are constantly emerging and are presenting with a wide range ... -
Novel opioids: systematic web crawling within the e-psychonauts’ scenario
Arillotta, Davide; Schifano, Fabrizio; Napoletano, Flavia; Zangani, Caroline; Gilgar, Liam; Guirguis, Amira; Corkery, John Martin; Aguglia, E; vento, alessandro (2020-03-18)Background: A wide range of novel psychoactive substances (NPSs) are regularly searched and discussed online by e-psychonauts. Among NPSs, the range of prescription/non-prescription opioids (fentanyl and non-fentanyl ... -
Psilocybin for Depression: From Credibility to Feasibility, What’s Missing?
Munafò, Antonio; Arillotta, Davide; Mannaioni, Guido; Schifano, Fabrizio; Bernardini, Renato; Cantarella, Giuseppina (2022-12-31)Psilocybin has been suggested as a promising transdiagnostic treatment strategy for a wide range of psychiatric disorders. Recent findings showed that psychedelic-assisted/”psycholitic” psychotherapy should provide significant ... -
The psychonauts' world of cognitive enhancers
Napoletano, Flavia; Schifano, Fabrizio; Corkery, John Martin; Guirguis, Amira; Arillotta, Davide; Zangani, Caroline; Vento, Alessandro (2020-09-11)Background: There is growing availability of novel psychoactive substances (NPS), including cognitive enhancers (CEs) which can be used in the treatment of certain mental health disorders. Whilst treating cognitive deficit ... -
Psychonauts’ psychedelics: a systematic, multilingual, web-crawling exercise
Catalani, Valeria; Corkery, John Martin; Guirguis, Amira; Napoletano, Flavia; Arillotta, Davide; Zangani, Caroline; Vento, Alessandro; Schifano, Fabrizio (2021-08-01)Psychedelics alter the perception of reality through agonist or partial agonist interaction with the 2A serotoninergic receptor. They are classified as phenethylamines, tryptamines and lysergamides. These classes, according ... -
Semaglutide as a Possible Calmodulin Binder: Ligand-Based Computational Analyses and Relevance to Its Associated Reward and Appetitive Behaviour Actions
Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Papanti Pelletier, G. Duccio; Corkery, John; Guirguis, Amira; Schifano, Fabrizio (2024-03-22)Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention as a therapeutic agent for type 2 diabetes mellitus and obesity. Despite its clinical success, the precise mechanisms ...