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Browsing by Author "Benham, Christopher"
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Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia
Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Lione, Lisa; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2017-05-17)Bladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and ... -
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
Anand, Uma; Otto, William R; Sanchez-Herrera, Daniel; Facer, Paul; Yiangou, Yiangos; Korchev, Yuri; Birch, Rolfe; Benham, Christopher; Bountra, Chas; Chessell, Iain P; Anand, Praveen (2008)Cannabinoid receptor 2 (CB2) agonists provide the potential for treating chronic pain states without CNS effects associated with CB1 receptor activation. Animal models suggest that they act mainly via non-neuronal cells, ... -
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum
Coletto, E; Dolan, John S; Pritchard, Sara; Gant, Alex; Hikima, Atsuko; Jackson, Michael J; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2019-06-10)Bowel dysfunction is a common non-motor symptom in Parkinson's disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in ... -
Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats
Shamsaldeen, Yousif; Ugur, Rosemary; Benham, Christopher; Lione, Lisa (2018-07-01)Background: Diabetes is a complex progressive disease characterised by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidised LDL (Ox-LDL) is elevated in diabetes and may contribute to ... -
Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats : Supplement to Diabetes Metab Res Rev. 34(5):e2995.
Lione, Lisa; Benham, Christopher; Shamsaldeen, Yousif (Biomedical Advances, 2019-08-13)Background: Diabetes is a complex progressive disease characterised by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidised LDL (Ox-LDL) is elevated in diabetes and may contribute to ... -
Dysfunction in nitric oxide synthesis in streptozotocin treated rat aorta and role of methylglyoxal
Shamsaldeen, Yousif; Alsugoor, Mahdi; Lione, Lisa; Benham, Christopher (2019-01-05)Diabetic vascular dysfunction is a major complication of diabetes. Methylglyoxal (MGO) is a dicarbonyl metabolite elevated in diabetic plasma that reacts with interstitial molecules to form advanced glycation end products ... -
Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes
Shamsaldeen, Yousif; Lione, Lisa; Benham, Christopher (2020-12-05)Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasorelaxation is impaired. The aim of this study was to examine the involvement of the TRPV4 ion channel in type 1 diabetic ... -
FUNCTIONAL AND HISTOLOGICAL CHANGES IN RAT URINARY BLADDER FOLLOWING SHORT AND LONG TERM KETAMINE EXPOSURE
Gant, Alex; Fergus, Suzanne; Benham, Christopher; Lione, Lisa (2020-11-18)Introduction: Due partly to their dissociative properties, ketamine and related new psychoactive substances (NPS) are widely used as recreational drugs. This has led to the discovery of a link between the chronic use of ... -
Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
Anagani, Bhavani; Singh, Jagbir; Bassin, Jatinder; Besra, Gurdyal; Benham, Christopher; Reddy, Tummala Rama Krishna; Cox, Jonathan; Goyal, Madhu (2020-05-18)Objectives: The search for new TB drugs has become one of the great challenges for modern medicinal chemistry. An improvement in the outcomes of TB chemotherapy can be achieved by the development of new, shorter, cheap, ... -
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies
Shamsaldeen, Yousif; MacKenzie, Louise; Lione, Lisa; Benham, Christopher (2016-05)Background: Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin dysfunction. Approximately 50% of diabetics show diabetes ... -
Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette
Sánchez, Daniel; Johnson, Nick; Li, Chao; Novak, Pavel; Rheinlaender, Johannes; Zhang, Yanjun; Anand, Uma; Anand, Praveen; Gorelik, Julia; Frolenkov, Gregory I; Benham, Christopher; Lab, Max; Ostanin, Victor P; Schäffer, Tilman E; Klenerman, David; Korchev, Yuri E (2008)Mechanosensitivity in living biological tissue is a study area of increasing importance, but investigative tools are often inadequate. We have developed a noncontact nanoscale method to apply quantified positive and negative ... -
Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta
Rehman, Atif ur; Dugic, Elma; Benham, Christopher; Lione, Lisa; MacKenzie, Louise Susan (2014)Abnormal vascular responsiveness in diabetes has been attributed to a number of changes in contractile pathways, affected in part by the overproduction of reactive oxygen species (ROS). It has been reported that NADPH ... -
The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)
Pritchard, Sara; Jackson, Michael; Lione, Lisa; Benham, Christopher; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M. (2013-12)Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common ... -
Synthesis and evaluation of chalcones and isobenzofuranones for their antimycobacterial activity.
Anagani, Bhavani; Bassin, Jatinder; Benham, Christopher; Goyal, Madhu (2015-11-26) -
Synthesis and Spectral Characterization of Benzo[6,7] [1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives
Bassin, Jatinder; Anagani, Bhavani; Benham, Christopher; Goyal, Madhu; Hashemian , Maryam; Gerhard, Ute (2016-07-23)A simple synthetic route to benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring system is developed from readily available starting materials 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline ...