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Browsing by Author "Benham, Christopher D"
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Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
Facer, Paul; Casula, Maria A; Smith, Graham D; Benham, Christopher D; Chessell, Iain P; Bountra, Chas; Sinisi, Marco; Birch, Rolfe; Anand, Praveen (2007)Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) ... -
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy
Sánchez, Daniel; Anand, Uma; Gorelik, Julia; Benham, Christopher D; Bountra, Chas; Lab, Max; Klenerman, David; Birch, Rolfe; Anand, Praveen; Korchev, Yuri (2007)Mechanosensitive ion channels convert external mechanical force into electrical and chemical signals in cells, but their physiological function in different tissues is not clearly understood. One reason for this is that ... -
Sensing of lysophospholipids by TRPC5 calcium channel
Flemming, Philippa K; Dedman, Alexandra M; Xu, Shang-Zhong; Li, Jing; Zeng, Fanning; Naylor, Jacqueline; Benham, Christopher D; Bateson, Alan N; Muraki, Katsuhiko; Beech, David J (2006)TRPC calcium channels are emerging as a ubiquitous feature of vertebrate cells, but understanding of them is hampered by limited knowledge of the mechanisms of activation and identity of endogenous regulators. We have ... -
Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration : role of glutamate receptors and voltage-dependent calcium channels
Cater, Heather L; Gitterman, Daniel; Davis, Susan M; Benham, Christopher D; Morrison, Barclay; Sundstrom, Lars E (2007)The relationship between an initial mechanical event causing brain tissue deformation and delayed neurodegeneration in vivo is complex because of the multiplicity of factors involved. We have used a simplified brain surrogate ...