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Browsing by Author "Cartwright, N."
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Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells : Comparison with Toll-like receptor 4 responses in macrophages
Moreno, L.; McMaster, S.K.; Gatheral, T.; Bailey, L.; Harrington, L.; Cartwright, N.; Armstrong, P.C.J.; Warner, T.D.; Paul-Clark, M.; Mitchell, J.A. (2010-08)Background and purpose: Gram-negative bacteria contain ligands for Toll-like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors. Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products ... -
The PPAR target gene CD36 is a rate limiting factor for the sensing of gram positive S-aureus in vascular smooth muscle cells but not in macrophages
Moreno, L.; McMaster, S.K.; Paul-Clark, M.; MacKenzie, Louise Susan; Cartwright, N.; Secher, T.; Quesniaux, V.; Ryffel, B.; Mitchell, J.A. (2008-08-01)Bacteria activate macrophages and vascular smooth muscle cells (VSMCs) resulting in induction of nitric oxide synthase (NOS)II activity. Here we show that the PPARc agonist rosiglitazone (rosi) increases the sensing of ...