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Browsing by Author "Cheng, W.P."
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The complexation between novel comb shaped amphiphilic polyallylamine and insulin : towards oral insulin delivery
Thompson, C.; Tetley, L.; Uchegbu, I.F.; Cheng, W.P. (2009)Novel amphiphilic polyallylamine (PAA) were previously synthesised by randomly grafting palmitoyl pendant groups and subsequent quaternising with methyl iodide. The ability of these self-assembled polymers to spontaneously ... -
In Vitro and In Vivo Anticancer Activity of a Novel Nano-sized Formulation Based on Self-assembling Polymers Against Pancreatic Cancer
Hoskins, C.; Ouaissi, M.; Lima, S.C.; Cheng, W.P.; Loureirio, I.; Mas, E.; Lombardo, D.; Cordeiro-da-Silva, A. (2010)Purpose: To evaluate the in vitro and in vivo pancreatic anticancer activity of a nano-sized formulation based on novel polyallylamine grafted with 5% mole cholesteryl pendant groups (CH5-PAA). Methods: Insoluble novel ... -
In vitro and in vivo characterisation of a novel peptide delivery system : Amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes
Cheng, W.P.; Thompson, C.; Ryan, S.M.; Aguirre, T.; Tetley, L.; Brayden, D.J. (2010)The cationic peptide, salmon calcitonin (sCT) was complexed with the cationic amphiphilic polyelectrolyte, poly(allyl)amine, grafted with palmitoyl and quaternary ammonium moieties at pH 5.0 and 7.4 to yield particulates ... -
A review on comb-shaped amphiphilic polymers for hydrophobic drug solubilization
Hoskins, C.; Thoo-Lin, P.K.; Cheng, W.P. (2012-01-01)Comb-shaped amphiphilic polymers are rapidly emerging as an alternative approach to amphiphilic block copolymers for hydrophobic drug solubilization. These polymers consist of a homopolymer or copolymer backbone to which ... -
Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-l-lysine nanocarrier to suppress prostate cancer growth in mice
Guo, J.; Cheng, W.P.; Gu, J.; Ding, C.; Qu, X.; Yang, Z.; O'Driscoll, C. (2012)Prostate cancer is associated with high mortality and new therapeutic strategies are necessary for improved patient outcome. The utilisation of potent, sequence-specific small interfering RNA (siRNA) to facilitate ... -
Uptake and transport of novel amphiphilic polyelectrolyte-insulin nanocomplexes by caco-2 cells - towards oral insulin
Thompson, C.; Cheng, W.P.; Gadad, P.; Skene, K.; Smith, M.; Smith, G.; McKinnon, A.; Knott, R. (2011)Purpose: The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated. Method: Polyallylamine (PAA) (15 kDa) was ...