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Browsing by Author "Cheong, Yuen-Ki"
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Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virus
Graham, Simon P.; Cheong, Yuen-Ki; Furniss, Summer; Nixon, Emma; Smith, Joseph A.; Yang, Xiuyi; Fruengel, Rieke; Hussain, Sabha; Tchorzewska, Monika A.; La Ragione, Roberto M.; Ren, Guogang (2021-08-20)Porcine reproductive and respiratory syndrome viruses (PRRSV) are responsible for one of the most economically important diseases affecting the global pig industry. On-farm high-efficiency particulate air (HEPA) filtration ... -
Applied Methods to Assess the Antimicrobial Activity of Metallic-Based Nanoparticles
Chung, Etelka; Ren, Guogang; Johnston, Ian; Matharu, Rupy Kaur; Ciric, Lena; Walecka, Agnieszka; Cheong, Yuen-Ki (2023-10-28)With the rise of antibiotic resistance, the drive to discover novel antimicrobial substances and standard testing methods with the aim of controlling transmissive diseases are substantially high. In healthcare sectors and ... -
AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats
Li, Junyang; Liu, Meicen; Gao, Jin; Jiang, Yu; Wu, Limin; Cheong, Yuen-Ki; Ren, Guogang; Yang, Zhuo (2020-07-01)Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients ... -
Cyclisation reactions of 2-substituted benzoylphosphonates with trialkyl phosphites via nucleophilic attack on a carbonyl-containing ortho substituent
Cheong, Yuen-Ki; Duncanson, Philip; Griffiths, D. Vaughan (2008-03-03)Dimethyl 2-acetoxy- and dimethyl 2-benzoyloxy-benzoylphosphonate undergo cyclisation and deoxygenation in the presence of excess trimethyl phosphite to give dimethyl (3-methyl-1-benzofuran-2-yl)phosphonate and dimethyl ... -
Electron-rich heteroaroylphosphonates and their reaction with trimethyl phosphite
Griffiths, D. Vaughan; Al-Jeboori, Mohamad J.; Cheong, Yuen-Ki; Duncanson, Philip; Harris, Jayne E.; Salt, Michael C.; Taylor, Helen V. (2008)Dialkyl heteroaroylphosphonates based on thiophene, pyrrole or furan have been prepared and their reactions with trimethyl phosphite investigated. Deoxygenation of the carbonyl groups in these heteroaroylphosphonates occurs ... -
Etidronate rescues cognitive deficits through improving synaptic transmission and suppressing apoptosis in 2-vessel occlusion model rats
Li, Wen; Yuan, Huijuan; Yu, Yao; Cheong, Yuen-Ki; Ren, Guogang; Yang, Zhuo (2017-01-20)Vascular dementia (VD) is a neurodegenerative disorder caused by the reduction of cerebral blood flow. It shows a progressive cognitive impairment. In our previous study, we found that etidronate (ET) showed neuroprotective ... -
The impact of ligand structure on the rhenium tricarbonyl complexes from tripodal pyridine-containing chelators
Cheong, Yuen-Ki; Duncanson, Philip; Griffiths, D. Vaughan; Motevalli, Majid (2010-08) -
Neuroprotective Effects of Etidronate and 2,3,3-Trisphosphonate Against Glutamate-Induced Toxicity in PC12 Cells
Li, Wen; Cheong, Yuen-Ki; Wang, Hui; Ren, Guogang; Yang, Zhuo (2016-04-01)Etidronate is one of the best known bisphosphonates (BP) derivatives. It is often used as a reference drug in research related to hypercalcaemia and other common bone diseases. 2,3,3-trisphosphonate (TrisPP) is brand new ... -
A novel approach to isoindolo[2,1-a]indol-6-ones
Duncanson, Philip; Cheong, Yuen-Ki; Motevalli, Majid; Griffiths, D. Vaughan (2012)A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl ... -
Novel Ylidic Phosphoryl Compounds from Halogenated Furan-2,5-Diones with Trivalent Phosphorus Esters: Application of this Approach to New Trisphosphonates Containing a Geminal Bisphosphonate Unit
Griffiths, D. Vaughan; Benoit, David M.; Cheong, Yuen-Ki; Duncanson, Philip; Han, Xiao (2014-08-03)The reactions of trivalent phosphorus esters, including trialkyl phosphites, dialkyl phosphonites, and alkyl phosphinites, with 3-halo- and 3,4-dihalo-furan-2,5-diones has been shown to lead to the formation of novel ... -
Studies of rheniumtricarbonyl complexes of tripodal pyridyl-based ligands
Griffiths, D. Vaughan; Al-Jeboori, Mohamad J.; Arnold, Phillip J.; Cheong, Yuen-Ki; Duncanson, Philip; Motevalli, Majid (2010-04-05)The reaction of N-benzoyl and N-acetyl tris(pyridin-2-yl)methylamine 1b and 1c (LH = tpmbaH and tpmaaH) with [Re(CO)5Br] has been investigated and shown to proceed via the initial formation of a cationic rheniumtricarbonyl ... -
Studies of the reactions of tripodal pyridine-containing ligands with Re(CO)5Br leading to rheniumtricarbonyl complexes with potential biomedical applications
Griffiths, D. Vaughan; Cheong, Yuen-Ki; Duncanson, Philip; Motevalli, Majid (2011)The complexes formed from the reaction of N-acylated tris-(pyridin-2-yl)methylamine (LH) with [Re(CO)5Br] depend on the structure of the ligand and the reaction conditions. Thus, while N-[1,1,1-tris-(pyridin-2-yl)methyl]acetamide ...