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Browsing by Author "Groot, P. H. E."
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Novel chemokine receptor inhibition assay
School of Life and Medical Sciences; Department of Pharmacy; Health & Human Sciences Research Institute; Medicinal and Analytical Chemistry; Berkhout, Theo; Groot, P. H. E.; Elshourbagy, Nabil; Bergsma, Derek; White, John R. (1998)Ligands MCP-4, MCP-3, RANTES, MCP-2, MCP-1 or eotaxin, has been identified for the G-protein receptor HGBER32. -
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076
Pearce, N. J.; Yates, J. W.; Berkhout, Theo; Jackson, B.; Tew, D.; Boyd, H.; Camilleri, P.; Sweeney, P.; Gribble, Andrew D.; Shaw, A.; Groot, P. H. E. (1998-08-15)ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological ...