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Browsing by Author "Grundy, David"
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Ageing and gastrointestinal sensory function : altered colonic mechanosensory and chemosensory function in the aged mouse
Keating, Christopher; Grundy, David (2015)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood (1). A feature of ageing is impaired sensory perception, including a diminished sensory response to inflammatory ... -
Ageing and Gastrointestinal Sensory Function : The Enteric Nervous System
Keating, Christopher; Grundy, David (2016-07-06)Over the past few decades a combination of electrophysiological, morphological and molecular approaches has enabled the different populations of vagal and spinal afferents that innervate the bowel to be characterized. The ... -
Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor dependent and independent mechanisms
Yu, Yang; Villalobos- Hernandez, Egina; Pradhananga, Sabindra; Baker, Corey; Keating, Christopher; Grundy, David; Lomax, Allan; Reed, David (2019-09-01)Increased bile acids in the colon can evoke increased epithelial secretion resulting in diarrhea, but little is known about whether colonic bile acids contribute to abdominal pain. This study aimed to investigate the ... -
In vitro recording of mesenteric afferent nerve activity in jejunal and colonic segments from rodents
Nullens, Sarah; Deiteren, Annemie; Jiang, Wen; Keating, Christopher; Ceuleers, Hannah; Franque, Sven; Grundy, David; de Man, Joris de Man; de Winter, Benedicte (2016-10-25)Afferent nerves not only convey information concerning normal physiology, but also signal disturbed homeostasis and pathophysiological processes of the different organ systems from the periphery towards the central nervous ... -
Intestinal Secretory and Absorptive Function in the Trichinella spiralis mouse model of Post-Infective Gut Dysfunction : role of bile acids
Kalia, N.; Hardcastle, J.; Grassi, Laura; Keating, Christopher; Pelegrin, Pablo; Bardhan, K.D.; Grundy, David (2008)Objective: Observations showing that bile acid malabsorption is frequent in irritable bowel syndrome (IBS) suggest that alterations in bile acid-induced secretion and absorption could contribute to IBS-associated diarrhoea. ... -
Post-infectious visceral hypersensitivity persists in the TRPV1 knockout mouse
Keating, Christopher; Grundy, David (2009-05) -
Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of post infectious bowel disease.
Rong, Weifang; Keating, Christopher; Sun, B.; Dong, L.; Grundy, David (2009-06)Increased sensitivity of the afferent innervation of the gastrointestinal tract reportedly underlies symptoms of discomfort and pain in functional bowel disorders. The present investigation aimed to examine whether the ... -
Translational potential of a mouse in-vitro bioassay in predicting gastrointestinal adverse drug reactions in phase 1 clinical trials
Keating, Christopher; Ewart, Lorna; Grundy, Luke; Valentin, Jean-Pierre; Grundy, David (2014-07)Background: Motility-related gastrointestinal adverse drug reactions (GADRs) such as diarrhoea and constipation are a common and deleterious feature associated with drug development. Novel biomarkers of GI function are ... -
The validation of an invitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions
Keating, Christopher; Ewart, Lornal; Gibbons, Stephen; Grundy, Luke; Valentin, Jean-Pierre; Grundy, David (2010-06)Motility-related gastrointestinal adverse drug reactions (GADRs), such as constipation and diarrhea, are some of the most frequently reported adverse events associated with the clinical development of new chemical entities, ...