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Browsing by Author "Gullick, D.R."
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Design, synthesis and characterisation of captopril prodrugs for enhanced percutaneous absorption
Moss, G.P.; Gullick, D.R.; Alexander, C.; Ingram, M.J.; Smart, J.D.; Pugh, W.J. (2006)Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for transdermal delivery. We were therefore interested in designing ... -
Mechanical characterisation and drug permeation properties of tetracaine-loaded bioadhesive films for percutaneous local anaesthesia
Moss, G.P.; Woolfson, A.D.; Gullick, D.R.; McCafferty, D.F. (2006)In the development of bioadhesive patch devices for percutaneous local anesthesia, the tensile properties of the films produced after the casting of the gel intermediates is of key importance to the clinical compliance of ... -
Metabolism of captopril carboxyl ester derivatives for percutaneous absorption
Gullick, D.R.; Ingram, M.J.; Pugh, W.J.; Cox, P.A.; Gard, P.; Smart, J.D.; Moss, G.P. (2009)To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare ...