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Browsing by Author "Jones, Stuart A."
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Controlling barrier penetration via exothermic iron oxidation
Wood, Daniel G.; Brown, Marc; Jones, Stuart A. (2011-02-14)Exothermic iron oxidation is an elegant means to generate heat, with the potential to modulate barrier penetration if reaction kinetics can be controlled. This aim of this study was to gain a fundamental understanding of ... -
Determination of polyvinylpyrrolidone using high-performance liquid chromatography
Jones, Stuart A.; Martin, Gary P.; Brown, Marc (2004-05-28)Polyvinylpyrrolidone (PVP) is a versatile polymer with innate surface activity. It is very difficult to accurately assay due to its wide molecular weight range and amphiphilic nature. This study evaluated a reversed-phase ... -
Determining degree of saturation after application of transiently supersaturated metered dose aerosols for topical delivery of corticosteroids
Jones, Stuart A.; Reid, Monica L.; Brown, Marc (2009-02)A transiently supersaturated drug delivery system has the potential to enhance topical drug delivery via heightened thermodynamic activity. The aim of this work was to quantify the degree of saturation (DS) for transiently ... -
Dynamic in-situ eutectic formation for topical drug delivery
Fiala, Sarah; Brown, Marc; Jones, Stuart A. (2011-11)Objectives: The relationship between the solution-state chemistry of eutectic systems and their transmembrane transport characteristics is difficult to define as these mixtures are sensitive to delivery vehicle-induced ... -
A dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situ
Zhao, Yanjun; Moddaresi, Mojgan; Jones, Stuart A.; Brown, Marc (2009-08)Topical nanoparticles are usually applied using semi-solid formulations, but the delivery process is often inefficient due to the poor drug release from the particles. The aim of this study was to investigate the capability ... -
Effects of lipid nanocarriers on the performance of topical vehicles in vivo
Moddaresi, Mojgan; Tamburic, Slobodanka; Williams, Stefanie; Jones, Stuart A.; Zhao, Yanjun; Brown, Marc (2009-06)Background/aims Nanocarrier systems have been extensively studied for their suitability in personal care formulations. Theoretically, they could enhance skin delivery of active compounds, thereby improving in vivo efficacy ... -
The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams
Zhao, Yanjun; Brown, Marc; Jones, Stuart A. (2010-01-04)Nanocarriers may act as useful tools to deliver therapeutic agents to the skin. However, balancing the drug-particle interactions; to ensure adequate drug loading, with the drug-vehicle interactions; to allow efficient ... -
The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers
Liao, Y. H.; Jones, Stuart A.; Nazir, T.; Martin, Gary P.; Brown, Marc (2005-11-04)The objective of the present study was to investigate the physical stability of spray-dried proteins within surfactant-free hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs) during prolonged storage. Two ... -
Engineering novel topical foams using hydrofluroalkane emulsions stabilised with pluronic surfactants
Zhao, Yanjun; Brown, Marc; Jones, Stuart A. (2009-06-28)Aesthetics are very important for topical products and as a consequence elegant vehicles such as sprays and foams are often preferred by patients. Pressurised systems are ideal to dose foams, however, as so little is known ... -
Free radical facilitated damage of ungual keratin
Khengar, Rajeshree H.; Brown, Marc; Turner, Rob B.; Traynor, M.J.; Holt, Katherine B.; Jones, Stuart A. (2010-09-01)Thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) are thought to disrupt alpha-keratin disulfide links in the nail However, optimal clinical use of these agents to improve the treatment of nail disorders is ... -
A fundamental investigation into the effects of eutectic formation on transmembrane transport
Fiala, Sarah; Jones, Stuart A.; Brown, Marc (2010-06-30)Eutectic systems enhance the permeation of therapeutic agents across biological barriers, but the mechanism by which this occurs has not previously been elucidated. Using human skin it has proven difficult to isolate the ... -
Ga(III) complexes-The effect of metal coordination on potential systemic absorption after topical exposure
Staff, Kirsten; Brown, Marc; Chilcott, Robert; Hider, Robert C.; Jones, Stuart A.; Kong, Xiao L. (2011-05-10)The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination ... -
High-pressure aerosol suspensions : A novel laser diffraction particle sizing system for hydrofluoroalkane pressurised metered dose inhalers
Jones, Stuart A.; Martin, Gary P.; Brown, Marc (2005-09-30)In this study, a novel laser diffraction particle size analysis dispersion system, capable of sizing particles in situ within suspension hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs), was developed and ... -
Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery
Brown, Marc; Jones, Stuart A.; He, Weijiang; Martin, Gary P. (American Chemical Society, 2006)Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and ... -
Hyaluronan: Pharmaceutical characterization and drug delivery
Liao, Y. H.; Jones, Stuart A.; Forbes, B.; Martin, Gary P.; Brown, Marc (2005)Hyaluronic acid ( HA), is a polyanionic polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is most frequently referred to as hyaluronan because it exists in vivo as a polyanion and not in ... -
Hyaluronic acid : a unique topical vehicle for the localized delivery of drugs to the skin
Brown, Marc; Jones, Stuart A. (2005-05)Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is present in the intercellular matrix of most vertebrate connective tissues ... -
An investigation into solvent-membrane interactions when assessing drug release from organic vehicles using regenerated cellulose membranes
Reid, Monica L.; Brown, Marc; Moss, Gary P.; Jones, Stuart A. (2008-09)The influence of organic solvents on artificial membranes when assessing drug release from topical formulations is, generally, poorly characterised yet current guidelines require no characterisation of the membrane before, ... -
An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes
Fiala, Sarah; Brown, Marc; Jones, Stuart A. (2008-12)Few studies have assessed the impact of binary systems on the fundamental mathematical models that describe drug permeation. The aim of this work was to determine the influence of varying the proportions of prilocaine and ... -
Manipulation of corticosteroid release from a transiently supersaturated topical metered dose aerosol using a residual miscible co-solvent
Reid, Monica L.; Brown, Marc; Jones, Stuart A. (2008-11)Purpose. The creation of supersaturation transiently after application overcomes the issue of drug instability. However, if the solvents used to drive supersaturation evaporate too quickly, drug recrystallisation or rapid ... -
The role of vehicle-nanoparticle interactions in topical drug delivery
Moddaresi, Mojgan; Brown, Marc; Zhao, Yanjun; Tamburic, Slobodanka; Jones, Stuart A. (2010-11-15)Loading 'difficult to deliver' therapeutic agents into lipid nanoparticles (LN) is an attractive means to administer them to the skin. However, employing colloidal carriers to administer therapeutic agents from semi-solid ...