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Browsing by Author "Kuoppamaki, M."
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3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
Iravani, Mahmoud M.; Jackson, M. J.; Kuoppamaki, M.; Smith, L. A.; Jenner, P. (2003-10-08)Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis ... -
MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome
Zeng, Bai-Yun; Iravani, Mahmoud M.; Lin, S. T.; Irifune, M.; Kuoppamaki, M.; Al-Barghouthy, G.; Smith, L.; Jackson, M. J.; Rose, S.; Medhurst, A.D.; Jenner, P. (2006-04)Dysfunction of the ubiquitin-proteasome system occurs in the substantia nigra (SN) in Parkinson's disease (PD). However, it is unknown whether this is a primary cause or a secondary consequence of other components of the ... -
Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia
Iravani, Mahmoud M.; Costa, S.; Al-Bargouthy, G.; Jackson, M. J.; Zeng, Bai-Yun; Kuoppamaki, M.; Obeso, J. A.; Jenner, P. (2005-09)Pallidotomy paradoxically reduces the intensity of levodopa-induced dyskinesia without worsening motor symptoms. The reasons for this are not clear and no experimental study has investigated this phenomenon. The objective ...