- UHRA Home
- Browsing by Author
Browsing by Author "Martin, Gary P."
Now showing items 1-20 of 41
-
Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
Moss, Gary; Sun, Yi; Wilkinson, Simon C.; Davey, N.; Adams, Roderick; Martin, Gary P.; Prapopopolou, M.; Brown, Marc (2011-11)Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ... -
Comparison of salmeterol xinafoate microparticle production by conventional and novel antisolvent crystallization
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-05)The production of microparticles for inhalation has relied on jet-milling while the potential for crystallization of microparticles has remained underexplored until relatively recently. Aqueous antisolvent crystallization ... -
Dermal and transdermal drug delivery systems : Current and future prospects
Brown, Marc; Martin, Gary P.; Jones, S. A.; Akomeah, F. K. (2006)The protective function of human skin imposes physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have adequate lipophilicity and ... -
Determination of polyvinylpyrrolidone using high-performance liquid chromatography
Jones, Stuart A.; Martin, Gary P.; Brown, Marc (2004-05-28)Polyvinylpyrrolidone (PVP) is a versatile polymer with innate surface activity. It is very difficult to accurately assay due to its wide molecular weight range and amphiphilic nature. This study evaluated a reversed-phase ... -
Developing an environmentally benign process for the production of microparticles : Amphiphilic crystallization
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-05)The production of microparticles for inhalation typically employs jet-milling which can be destructive to the solid-state properties of the particles. The objective of the current work was to develop a crystallization ... -
Dry Powder Formulations for Inhalation of Fluticasone Propionate and Salmeterol Xinafoate Microcrystals
Murnane, Darragh; Martin, Gary P.; Marriott, Christopher (2009-02)Direct crystallization of active pharmaceutical ingredient (API) particles in the inhalable size range of 1-6 mu m may overcome surface energization resulting from micronization. The aerosolization of fluticasone propionate ... -
Effect of abrasion induced by a rotating brush on the skin permeation of solutes with varying physicochemical properties
Akorneah, Franklin K.; Martin, Gary P.; Muddle, Andy G.; Brown, Marc (2008-03)A transient reduction in the barrier nature of the skin can be a pre-requisite for successful (trans)dermal delivery of some drugs. The aim of this present study was to investigate and effect of a dermal abrading "rotating ... -
The effect of hyaluronan on the in vitro deposition of diclofenac within the skin
Brown, Marc; Marriott, C.; Martin, Gary P. (1995)Hyaluronan is a glycosaminoglycan and has a protective, shock-absorbing and structure-stabilizing role in connective tissue. Recently, ii has been suggested that hyaluronan can be used as a controlled and localized delivery ... -
Effect of molecular weight and concentration hyaluronan on the in-vitro release characteristics of ibuprofen and diclofenac sodium across cellulose membrane
He, W. J.; Brown, Marc; Martin, Gary P. (2004-09)Hyaluronan (HA) is a naturally occurring polyanionic glycosaminoglycan. Drugs formulated in HA and applied topically are retained in the skin with little systemic absorption (Brown et al 2000, 2001). However, the precise ... -
The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers
Liao, Y. H.; Jones, Stuart A.; Nazir, T.; Martin, Gary P.; Brown, Marc (2005-11-04)The objective of the present study was to investigate the physical stability of spray-dried proteins within surfactant-free hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs) during prolonged storage. Two ... -
Evidence for the existence of powder sub-populations in micronized materials : Aerodynamic size-fractions of aerosolized powders possess distinct physicochemical properties
Jaffari, Sara; Forbes, Ben; Collins, Elizabeth; Khoo, Jiyi; Martin, Gary P.; Murnane, Darragh (2014-12-31)Purpose: To investigate the agglomeration behaviour of the fine (< 5.0 µm) and coarse (> 12.8 µm) particle fractions of salmeterol xinafoate (SX) and fluticasone propionate (FP) by isolating aerodynamic size fractions and ... -
Formulation pre-screening of inhalation powders using computational atom-atom systematic search method
Ramachandran, Vasuki; Murnane, Darragh; Hammond, Robert B.; Pickering, Jonathan; Roberts, Kevin J.; Soufian, Majeed; Forbes, Ben; Jaffari, Sara; Martin, Gary P.; Collins, Elizabeth; Pencheva, Klimentina (2015-01-05)The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes. This study aimed to investigate the ... -
High performance liquid chromatography of a cyclosporin A formulation on a porous graphitic carbon column
Nazir, T.; Gould, L. A.; Marriott, C.; Martin, Gary P.; Brown, Marc (1997-12)A porous graphitic column (PGC) column was employed as a stationary phase at high temperature to effect the separation of cyclosporin A (CyA) and cyclosporin U (CyU). A robust assay for the former in liposomes was also ... -
High-pressure aerosol suspensions : A novel laser diffraction particle sizing system for hydrofluoroalkane pressurised metered dose inhalers
Jones, Stuart A.; Martin, Gary P.; Brown, Marc (2005-09-30)In this study, a novel laser diffraction particle size analysis dispersion system, capable of sizing particles in situ within suspension hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs), was developed and ... -
Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery
Brown, Marc; Jones, Stuart A.; He, Weijiang; Martin, Gary P. (American Chemical Society, 2006)Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and ... -
Hyaluronan: Pharmaceutical characterization and drug delivery
Liao, Y. H.; Jones, Stuart A.; Forbes, B.; Martin, Gary P.; Brown, Marc (2005)Hyaluronic acid ( HA), is a polyanionic polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is most frequently referred to as hyaluronan because it exists in vivo as a polyanion and not in ... -
In situ and Ex situ analysis of salmeterol xinafoate microcrystal formation from poly(ethylene glycol) 400 - Water cosolvent mixtures
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-06)Salmeterol xinafoate (SX) crystallization was investigated under different conditions of stirring, antisolvent addition, and supersaturation to identify factors limiting particle growth to enable the production of respirable ... -
An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs
Brown, Marc; Hanpanitcharoen, M; Martin, Gary P. (2001-08-28)Recently, Solaraze gel (Bioglan, Herts, UK) a topical hyaluronan (HA)/dictofenac formulation for the treatment of actinic keratosis has received regulatory approval in the US, Canada and Europe for the treatment of actinic ... -
An in vitro investigation of the mode of action of hyaluronan as a drug delivery vehicle using circular dichroism
Brown, Marc; Siligardi, G.; Martin, Gary P.; Drake, A.; Marriott, C. (Royal Society of Medicine Press, 1995)