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Browsing by Author "McKellar, Quintin"
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The absorption, distribution and elimination of anthelmintic drugs : the role of pharmacokinetics
Baggot, J. D.; McKellar, Quintin (1994-12) -
Ampicillin and its congener prodrugs in the horse
Sarasola, P.; McKellar, Quintin (1994-03)Ampicillin is an antibiotic commonly administered to horses by both the intramuscular (i.m.) and the intravenous (i.v.) route. Its physicochemical properties restrict its absorption after oral administration and explain ... -
Animal Health and the Role of Pharmaceuticals
McKellar, Quintin (2001) -
Anti-inflammatory effects of carprofen, carprofen enantiomers, and NG-nitro-L-arginine methyl ester in sheep
Cheng, Z.; Nolan, A.; McKellar, Quintin (2002-06)Objective-To assess anti-inflammatory effects of carprofen (CPF), CPF enantiomers, and N(G)-nitro-L-arginine methyl ester (L-NAME) in sheep. Animals-8 sheep. Procedure-Sheep with SC tissue cages were used. After intracaveal ... -
Antibiotics and resistance in farm animals
McKellar, Quintin (1999)Antibiotics are used in animals to cure disease and prevent suffering. Bacterial populations in animals which are exposed to these antibiotics may be selected for resistance. There is a concern that spread of these bacteria ... -
Antimicrobial resistance: a veterinary perspective
McKellar, Quintin (1998-09-05)Bacterial disease is a major constraint on the efficient production of animal derived food and causes ill health and suffering in both food producing and companion animals. In some production systems the spread of bacterial ... -
Avermectins and milbemycins
McKellar, Quintin; Benchaoui, H. A. (1996-10) -
The benzimidazole anthelmintic agents - a review
McKellar, Quintin; Scott, E. W. (1990) -
Benzimidazole resistance in a herd of horses
Love, S.; McKellar, Quintin; Duncan, J. L. (1989) -
Benzimidazole resistance in nematodes of goats
Scott, E. W.; Bairden, K.; Holmes, P. H.; McKellar, Quintin (1989-05) -
Bioavailability of different benzimidazole volume-dose formulations in sheep
Benchaoui, H. A.; Futter, I. J.; Holton, L. L.; Gettinby, G.; McKellar, Quintin (1995) -
Changes in the zymogenic cell populations of the abomasa of sheep infected with Haemonchus contortus
Scott, I.; Stear, M.J.; Irvine, J.; Dick, A.; Wallace, D.S.; McKellar, Quintin (1998-06)The effects of dietary urea supplementation and of a 10-week trickle infection regime, simulating chronic exposure to Haemonchus contortus, on the zymogenic population of the abomasa of Hampshire Down lambs was examined, ... -
Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses
Sanchez Bruni, S. F.; Fusé, L.A.; Moreno, L.; Saumell, C.A.; Alvarez, L.I.; Fiel, C.; McKellar, Quintin; Lanusse, C.E. (2005-05)Reasons for performing the study: The study of novel pharmacological strategies to control parasitism in horses is required since many parasite species have developed resistance to anthelmintic drugs.Objectives: To evaluate ... -
Chemotherapy and delivery systems - helminths
McKellar, Quintin (1994-08)The milbemycins are the only novel broad spectrum anthelmintic chemicals to reach the market place in the last 10 years. Many new systems for delivery and strategies for rational use have, however, been introduced. Boluses ... -
Chronobiological variations of indomethacin pharmacokinetic parameters in sheep
Boggio, J.C.; Valtorta, S.E.; Sanchez, S.; McKellar, Quintin (2001-08)A two-phase study to investigate the influence of administration time on pharmacokinetics of indomethacin in sheep was performed. In phase I, 12 animals were allocated to four groups, each corresponding to a different time: ... -
Clinical and pharmacological properties of ivermectin in rabbits and guinea pigs
McKellar, Quintin; Midgley, D. M.; Galbraith, E. A.; Scott, E. W.; Bradley, A. (1992-01)When 400 micrograms ivermectin/kg was administered subcutaneously to rabbits infected with the ear mite Psoroptes cuniculi it significantly reduced the clinical score, and when 500 micrograms ivermectin/kg was administered ... -
Clinical relevance of the pharmacologic properties of fluoroquinolones
McKellar, Quintin (1996) -
Comparative field evaluation of divided-dosing and reduced feed intake upon treatment efficacy against resistant isolates of Teladorsagia circumcincta in sheep and goats
Barrett, M.; Jackson, F.; Patterson, M.; Jackson, E.; McKellar, Quintin (1998-03)The effects of modifying drug administration and food intake upon the efficacy of fenbendazole against resistant isolates of Teladorsagia (Ostertagia) circumcincta were investigated using naturally infected sheep and goats. ... -
Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats
Ali, B.H.; Cheng, Z.; Hadrami, G.; Bashir, A.K.; McKellar, Quintin (1996-06)Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 +/- 1.4 ml/mL . kg vs, 52.8 +/- ... -
Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs
Gokbulut, C.; Bilgili, A.; Hanedan, B.; McKellar, Quintin (2007)The plasma disposition of fenbendazole (FBZ), oxfendazole (OFZ) and albendazole (ABZ); and the enantiospecific disposition of OFZ, and ABZSO produced were investigated following an oral administration (50 mg/kg) in dogs. ...