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Browsing by Author "Mitchell, Jane A."
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Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation : implications for a clinical test
Kirkby, Nick; Chan, M.V.; Lundberg, M.H.; MacKenzie, Louise; Leadbeater, Phillip D.M.; Milne, Ginger L.; Potter, Claire M.; Al-Yamani, Malak; Adeyemi, Oladipupo; Warner, Tim D.; Mitchell, Jane A. (2013-10)Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin ... -
Contribution of COX1 and COX2 to prostacyclin release by healthy mouse tissues
Kirkby, N.S.; Harrington, Louise; Lundberg, Martina; Hoefer, T.; Warner, Tim D.; Mitchell, Jane A. (2011-06) -
COX isoforms in aortic endothelial cells from young adult and mature adult mice
Lundberg, M.H.; MacKenzie, Louise Susan; Vojnovic, Ivana; Warner, Timothy D.; Mitchell, Jane A. (2009) -
COX-1 or COX-2 deletion is associated with increased nuclear NF-κB in the endothelium of the aortic arch.
Lundberg, Martina; Harrington, Louise Susan; Leadbeater, Phillip D.M.; Warner, Tim D.; Mitchell, Jane A. (2010) -
The ‘EDHF’ Antagonist 14, 15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Vessels
MacKenzie, Louise Susan; Falck, John R.; Mitchell, Jane A. (2004-07)There is now overwhelming evidence for Epoxyeicosatrienoic acids (EETs) as endothelial derived hyperpolarising factor (EDHF). Most recently, a number of pharmacological tools have been developed for the study of EETs in ... -
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sarah; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-02-17)BACKGROUND: Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased ... -
A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension
Mohamed, Nura A.; Ahmetaj-Shala, Blerina; Duluc, Lucie; Mackenzie, Louise S.; Kirkby, Nicholas S.; Reed, Daniel M.; Lickiss, Paul D.; Davies, Robert P.; Freeman, Gemma R.; Wojciak-Stothard, Beata; Chester, Adrian H.; El-Sherbiny, Ibrahim M.; Mitchell, Jane A.; Yacoub, Magdi H. (2016-04)Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and ... -
Nitric oxide-dependent vasodilation is compromised in isolated pulmonary arteries from COX knockout mice
Wright, Will; MacKenzie, Louise Susan; Kirkby, N.S.; Mitchell, Jane A. (2013-04)Cyclooxygenase (COX) has two isoforms and is essential for prostanoid synthesis. COX-1 is constitutive whilst COX-2 is induced in inflammation. Two COX products, prostacyclin (PGI2) and thromboxane (TxA2), regulate vessel ... -
Not so EEZE : the ‘EDHF’ antagonist 14, 15 Epoxyeicosa-5(z)-enoic Acid has vasodilator properties in mesenteric arteries
MacKenzie, Louise Susan; Falck, John R.; Mitchell, Jane A. (2004-12-15)P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic ... -
Relative expression of cyclo-oxygenase COX-1 and COX-2 in porcine endothelium subjected to chronic shear stress
Potter, Claire M.F.; Lundberg, Martina H.; MacKenzie, Louise Susan; Warboys, C.M.; Gashaw, Hime; Warner, Timothy D.; Weinberg, P.D.; Mitchell, Jane A. (2009) -
Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine : Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs"
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sara; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise Susan; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-10-27) -
Role of prostacyclin in pulmonary hypertension
Mitchell, Jane A.; Ahmetaj-Shala, Blerina; Kirkby, Nick; Wright, William R.; MacKenzie, Louise Susan; Reed, Dan; Mohamed, Nura (2014-12-31)Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads ...