- UHRA Home
- Browsing by Author
Browsing by Author "Najib, Omaima N."
Now showing items 1-3 of 3
-
Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compounds
Najib, Omaima N.; Martin, Gary P; Kirton, Stewart; Sallam, Al-Sayed; Murnane, Darragh (2016-06-15)The diffusion process through a non-porous barrier membrane depends on the properties of the drug, vehicle and membrane. The aim of the current study was to investigate whether a series of oily vehicles might have the ... -
The influence of oily vehicle composition and vehicle-membrane interactions on the diffusion of model permeants across barrier membranes
Najib, Omaima N.; Martin, Gary P.; Kirton, Stewart B.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2021-01-14)In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the potential of preferential uptake of one oily vehicle component ... -
Multivariate analytical approaches to identify key molecular properties of vehicles, permeants and membranes that affect permeation through membranes
Najib, Omaima N.; Kirton, Stewart B.; Martin, Gary P.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2020-10-31)There has been considerable recent interest in employing computer models to investigate the relationship between the structure of a molecule and its dermal penetration. Molecular permeation across the epidermis has previously ...