- UHRA Home
- Browsing by Author
Browsing by Author "Nanopharmaceutics"
Now showing items 1-20 of 156
-
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
5.08 Drug Delivery across the Blood-brain barrier
Lalatsa, Aikaterini (Elsevier, 2011) -
Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
Active Targeting
Serrano Lopez, Dolores Remedios; Lalatsa, Lalatsa (Springer Nature, 2013) -
Advances in oral transmucosal drug delivery
Patel, Viralkumar F.; Liu, Fang; Brown, Marc (2011-07-30)The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ... -
Amphiphilic poly(l-amino acids) : New materials for drug delivery
Lalatsa, Aikaterini; Schaetzlein, Andreas G.; Mazza, Mariarosa; Thi Bich Hang Le, [No Value]; Uchegbu, Ijeoma F. (2012-07-20)The formulation of drug compounds into medicines will increasingly rely on the use of specially tailored molecules, which fundamentally alter the drug's pharmacokinetics to enable its therapeutic activity. This is particularly ... -
Analysis of 'legal high' substances and common adulterants using handheld spectroscopic techniques
Assi, Sulaf; Guirguis, Amira; Halsey, S.; Fergus, S.; Stair, J. L. (2015-01)The identification of 'legal highs' is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniques to be on-site, rapid ... -
The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
Moss, Gary; Sun, Yi; Wilkinson, Simon C.; Davey, N.; Adams, Roderick; Martin, Gary P.; Prapopopolou, M.; Brown, Marc (2011-11)Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ... -
The application of feature selection to the development of Gaussian process models for percutaneous absorption.
Lam, L.T.; Sun, Yi; Davey, N.; Adams, Roderick; Prapopoulou, M.; Brown, Marc; Moss, Gary (2010)Objectives: The aim was to employ Gaussian processes to assess mathematically the nature of a skin permeability dataset and to employ these methods, particularly feature selection, to determine the key physicochemical ... -
Application of sebomics for the analysis of residual skin surface components to detect potential biomarkers of type-1 diabetes mellitus
Shetage, Satyajit S; Traynor, Matthew J; Brown, Marc B; Galliford, Thomas M; Chilcott, Robert P (2017-08-21)Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate and ... -
Assessment of a cyclone-type spacer device for use in dry powder inhalation
Parisini, I.; Cheng, S. J.; Symons, D. D.; Brown, Marc; Kostrzewski, A.; Murnane, D. (2013-08)Dry powder inhalers (DPIs) are used widely in asthma and chronic obstructive pulmonary disease therapies. However, the lung deposition from DPIs is highly variable and patients with poor lung function can struggle to achieve ... -
Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Corkery, John M; Stair, Jacqueline L; Schifano, Fabrizio; Guirguis, Amira (2024-01-12)Introduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around ... -
Blood-Brain Barrier Delivery Session Podium Presentation : Carbohydrate Amphiphiles Enable Oral Peptide Delivery to the Central Nervous System
Lalatsa, Aikaterini; Schatzlein, A. G.; Uchegbu, I.F. (2009) -
Carbohydrate Amphiphiles Enable Peptide Delivery to the CNS
Lalatsa, Aikaterini; Schatzlein, A. G.; Uchegbu, I.F. (2008) -
Characterization of latent heat-releasing phase change materials for dermal therapies
Wood, D.G.; Brown, Marc; Jones, S. A.; Murnane, D. (2011-04-28)Phase change materials (PCMs) have been developed as heat storage solutions, particularly for the supply of “green” energy. One interesting use of PCMs is long-term energy storage, in which a phase transition is triggered ... -
Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro
Stewart, C.A.; Turner, Rob B.; Brown, Marc; Traynor, M.J. (Royal Society of Chemistry, 2014-04-14)Any chemical that is applied to the skin has the potential to induce a skin reaction. These reactions are complicated and are difficult to fully replicate in vitro and may exhibit species variations when reproduced in vivo. ... -
Collection and characterisation of residual skin surface components obtained from sebum, sweat and epidermal lipids
Shetage, S.S.; Traynor, M.J.; Brown, Marc; Chilcott, Robert (Royal Society of Chemistry, 2014-04-14)Collection and analysis of skin surface lipids or sebum has been reported in several previous studies where Sebutape™, polyurethane foam, cigarette paper and organic solvents were used to acquire samples, analysis of which ... -
A comparison of topical formulations for the prevention of human schistosomiasis
Cooper, E.; Iqbal, A.; Bartlett, A.; Marriott, C.; Whitfield, P.J.; Brown, Marc (2004-08)Recently, a dimeticone formulation has been shown to be effective at preventing Schistosoma cercariae infecting skin, while DEET (N,N-diethyl-m-toluamide), a highly effective insecticide, has been shown to have activity ... -
Controlling barrier penetration via exothermic iron oxidation
Wood, Daniel G.; Brown, Marc; Jones, Stuart A. (2011-02-14)Exothermic iron oxidation is an elegant means to generate heat, with the potential to modulate barrier penetration if reaction kinetics can be controlled. This aim of this study was to gain a fundamental understanding of ... -
Controlling the disposition of gallium complexes in human skin using iontophoresis
Staff, K.; Jones, S. A.; Brown, Marc (2010-06)