Browsing by Author "Patel, Aateka"

Now showing items 1-3 of 3

    • Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis 

      Dexter, Alex; Steven, Rory T; Patel, Aateka; Dailey, Lea Ann; Taylor, Adam J; Ball, Doug; Klapwijk, Jan; Forbes, Ben; Page, Clive P; Bunch, Josephine (2019-12)
      Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry ...

    • Profiling alveolar macrophage responses to inhaled compounds using in vitro high content image analysis 

      Hoffman, Ewelina; Urbano, Laura; Martin, Abigail; Mahendran, Rhamiya; Patel, Aateka; Murnane, Darragh; Page, Clive; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2023-09-01)
      One of the main hurdles in the development of new inhaled medicines is the frequent observation of foamy macrophage (FM) responses in non-clinical studies in experimental animals, which raises safety concerns and hinders ...

    • Using salt counterions to modify β2-agonist behaviour in vivo 

      Patel, Aateka; Rudman, Sandra Dhian; Brown, Marc; Hider, Robert Charles; Jones, Stuart Allen; Page, Clive Peter (2016-10-03)
      There is a paucity of data describing the impact of salt counterions on the biological performance of inhaled medicines in vivo. The aim of this study was to determine if the coadministration of salt counterions influenced ...