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3D Characterisation of Dry Powder Inhaler Formulations: Developing X-ray Micro Computed Tomography Approaches
Gajjar, P; Styliari, I D; Nguyen, T T H; Carr, J; Chen, X; Elliott, J A; Hammond, R B; Burnett, T L; Roberts, K; Withers, P J; Murnane, D (2020-06)Carrier-based dry powder inhaler (DPI) formulations need to be accurately characterised for their particle size distributions, surface roughnesses, fines contents and flow properties. Understanding the micro-structure of ... -
5.08 Drug Delivery across the Blood-brain barrier
Lalatsa, Aikaterini (Elsevier, 2011) -
Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro
Dalton, Christopher H.; Hattersley, Ian J.; Rutter, Stephen J.; Chilcott, Robert (2006-12)The physico-chemical properties of VX make the skin the most likely route of absorption into the human body. The development of effective medical countermeasures against such percutaneous threat agents relies on the use ... -
Acceptability in the Older Population: The Importance of an Appropriate Tablet Size
Vallet, Thibault; Michelon , Hugues; Orlu, Mine; Jani, Yogini Hariprasad; Leglise , Patrick; Laribe-Caget , Sandra; Piccoli, Matthieu; Le Fur , Aurélie; Liu, Fang; Ruiz , Fabrice; Boudy , Vincent (2020-08-08)Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia ... -
Acceptability of oral solid medicines in older adults with and without dysphagia : a nested pilot validation questionnaire based observational study
Liu, Fang; Ghaffur, Ambreen; Bains, Jackreet; Hamdy, Shaheen (2016-10-30)Older patients (aged 65 years and over) are the major consumers of medicines and many barriers affect their ability in taking medicines orally, especially swallowing difficulties. Moreover, the characteristics of differing ... -
Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
Active Targeting
Serrano Lopez, Dolores Remedios; Lalatsa, Lalatsa (Springer Nature, 2013) -
Advances in oral transmucosal drug delivery
Patel, Viralkumar F.; Liu, Fang; Brown, Marc (2011-07-30)The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ... -
Age-mediated changes in the gastrointestinal tract
Merchant, Hamid; Liu, Fang; Orlu Gul, Mine; Basit, Abdul (2016-10-30)Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of ... -
Amphiphilic poly(l-amino acids) : New materials for drug delivery
Lalatsa, Aikaterini; Schaetzlein, Andreas G.; Mazza, Mariarosa; Thi Bich Hang Le, [No Value]; Uchegbu, Ijeoma F. (2012-07-20)The formulation of drug compounds into medicines will increasingly rely on the use of specially tailored molecules, which fundamentally alter the drug's pharmacokinetics to enable its therapeutic activity. This is particularly ... -
Apparatus, buffer and method for pH control
School of Life and Medical Sciences; Department of Clinical and Pharmaceutical Sciences; Centre for Research into Topical Drug Delivery and Toxicology; Pharmaceutics; Pharmaceutical Analysis and Product Characterisation; Bioadhesive Drug Delivery Group; Liu, Fang; Curl, Andrew; Fitzgerald , Dean (2019-04) -
The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
Moss, Gary; Sun, Yi; Wilkinson, Simon C.; Davey, N.; Adams, Roderick; Martin, Gary P.; Prapopopolou, M.; Brown, Marc (2011-11)Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ... -
The application of feature selection to the development of Gaussian process models for percutaneous absorption.
Lam, L.T.; Sun, Yi; Davey, N.; Adams, Roderick; Prapopoulou, M.; Brown, Marc; Moss, Gary (2010)Objectives: The aim was to employ Gaussian processes to assess mathematically the nature of a skin permeability dataset and to employ these methods, particularly feature selection, to determine the key physicochemical ... -
Application of sebomics for the analysis of residual skin surface components to detect potential biomarkers of type-1 diabetes mellitus
Shetage, Satyajit S; Traynor, Matthew J; Brown, Marc B; Galliford, Thomas M; Chilcott, Robert P (2017-08-21)Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate and ... -
Assessment of a cyclone-type spacer device for use in dry powder inhalation
Parisini, I.; Cheng, S. J.; Symons, D. D.; Brown, Marc; Kostrzewski, A.; Murnane, D. (2013-08)Dry powder inhalers (DPIs) are used widely in asthma and chronic obstructive pulmonary disease therapies. However, the lung deposition from DPIs is highly variable and patients with poor lung function can struggle to achieve ... -
Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development
Merchant, Hamid A.; McConnell, Emma L.; Liu, Fang; Ramaswamy, Chandrasekaran; Kulkarni, Rucha P.; Basit, Abdul W.; Murdan, Sudaxshina (2011-01-18)Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem ... -
Assessment of swallowability and palatability of oral dosage forms in children : Report from an M-CERSI pediatric formulation workshop
Ternik, Robert; Liu, Fang; Bartlett, Jeremy A; Khong, Yuet Mei; Thiam Tan, David Cheng; Dixit, Trupti; Wang, Siri; Galella, Elizabeth A; Gao, Zhihui; Klein, Sandra (2018-02-05)The acceptability of pediatric pharmaceutical products to patients and their caregivers can have a profound impact on the resulting therapeutic outcome. However, existing methodology and approaches used for acceptability ... -
ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes
McAuley, W. J.; Lad, M. D.; Mader, K. T.; Santos, P.; Tetteh, J.; Kazarian, S. G.; Hadgraft, J.; Lane, M. E. (2010-02)The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. ... -
Biophysical measurements of human forearm, skin in vivo : effects of site, gender, chirality and time
Chilcott, Robert; Farrar, R. (2000-05)Background/aims: Measurements of transepidermal water loss (TEWL) and skin colour are biophysical techniques commonly used to measure the in vivo skin effects of cosmetics, topical medicaments and chemical irritants. The ... -
Blood-Brain Barrier Delivery Session Podium Presentation : Carbohydrate Amphiphiles Enable Oral Peptide Delivery to the Central Nervous System
Lalatsa, Aikaterini; Schatzlein, A. G.; Uchegbu, I.F. (2009)