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Browsing by Author "Robbins, Trevor W."
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Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study
Parkin, Kaherine; Chen, Shanquan; Biria, Marjan; Plaistow, James; Beckwith, Helen; Jarratt-Barnham, Isaac; Segarra, Nuria; Worbe, Yulia; Fineberg, Naomi; Cardinal, Rudolf N; Robbins, Trevor W.; Fernandez-Egea, Emilio (2023-05-13)Background Obsessive–compulsive symptoms (OCS) are commonly associated with clozapine treatment but are frequently overlooked by clinicians despite their potential impact on patients' quality of life. In this study, we ... -
Compulsivity Reveals a Novel Dissociation between Action and Confidence
Vaghi, Matilde M.; Luyckx, Fabrice; Sule, Akeem; Fineberg, Naomi A.; Robbins, Trevor W.; De Martino, Benedetto (2017-10-11)Confidence and actions are normally tightly interwoven—if I am sure that it is going to rain, I will take an umbrella—therefore, it is difficult to understand their interplay. Stimulated by the ego-dystonic nature of ... -
A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD
Biria, Marjan; Huang, Fiona-Xiaofei; Worbe, Yulia; Fineberg, Naomi; Robbins, Trevor W.; Fernandez-Egea, Emilio (2019-08-01)A large proportion of schizophrenia patients treated with second generation antipsychotics will develop Obsessive Compulsive Disorder (OCD). However, there are few studies about the impact of this comorbidity and who is ... -
Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder
Gillan, Claire M.; Papmeyer, Martina; Morein-Zamir, Sharon; Sahakian, Barbara J.; Fineberg, Naomi; Robbins, Trevor W.; de Wit, Sanne (2011-07)Objective: Obsessive-compulsive disorder (OCD) is characterized by repetitive, ritualistic behaviors and thought patterns. Although patients with OCD report that these compulsive behaviors are unproductive and often ... -
Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder
Murray, Graham; Knolle, Franziska; Ersche, Karen D; Craig, Kevin J; Abbott, Sanja; Shabbir, Shaila S; Fineberg, Naomi; Suckling, John; Sahakian, Barbara J.; Bullmore, Edward T.; Robbins, Trevor W. (2019-08-01)Rationale: Patients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior ... -
The effects of acute serotonin challenge on executive planning in patients with obsessive-compulsive disorder (OCD), their first-degree relatives, and healthy controls
Lochner, Christine; Chamberlain, Samuel R.; Kidd, Martin; Fineberg, Naomi; Robbins, Trevor W.; Stein, D.J. (2020-07-08)Rationale: OCD is characterized by executive function impairment and by clinical responsivity to selective serotonin reuptake inhibitors (SSRIs). Executive planning deficits constitute a candidate endophenotype for OCD. ... -
Free operant observing in humans : A translational approach to compulsive certainty seeking
Morein-Zamir, Sharon; Shahper, Sonia; Fineberg, Naomi; Eisele, Verena; Eagle, Dawn M.; Urcelay, Gonzalo; Robbins, Trevor W. (2018-10-01)Excessive checking is reported in non-clinical populations and is a pervasive symptom in obsessive compulsive disorder (OCD). We implemented a free-operant task in humans, previously used in rats, wherein participants can ... -
Hypoactivation and Dysconnectivity of a Frontostriatal Circuit During Goal-Directed Planning as an Endophenotype for Obsessive-Compulsive Disorder
Vaghi, Matilde M.; Hampshire, Adam; Kaser, Muzaffer; Fineberg, Naomi; Brühl, Annette B.; Sahakian, Barbara J.; Chamberlain, Samuel R.; Robbins, Trevor W. (2017-11-01)Background The symptoms of obsessive-compulsive disorder (OCD) have been postulated to result from impaired executive functioning and excessive habit formation at the expense of goal-directed control and have been objectively ... -
Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder
Hampshire, Adam; Zadel, Ana; Sandrone, Stefano; Soreq, Eyal; Fineberg, Naomi; Bullmore, Edward T.; Robbins, Trevor W.; Sahakian, Barbara J.; Chamberlain, Samuel R. (2020-02)BACKGROUND: Obsessive-compulsive disorder (OCD) is a prevalent neuropsychiatric condition, with biological models implicating disruption of cortically mediated inhibitory control pathways, ordinarily serving to regulate ... -
Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search
Morein-Zamir, Sharon; Papmeyer, Martina; Durieux, Alice; Fineberg, Naomi A.; Sahakian, Barbara J.; Robbins, Trevor W. (2013-11-08)Whether Obsessive Compulsive Disorder (OCD) is associated with an increased attentional bias to emotive stimuli remains controversial. Additionally, it is unclear whether comorbid depression modulates abnormal emotional ... -
Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders : Cognitive Domains, Neural Circuitry, and Treatment
Fineberg, Naomi A.; Apergis-Schoute, Annemieke M.; Vaghi, Matilde M.; Banca, Paula; Gillan, Claire M.; Voon, Valerie; Chamberlain, Samuel R.; Cinosi, Eduardo; Reid, Jemma; Shahper, Sonia; Bullmore, Edward T.; Sahakian, Barbara J.; Robbins, Trevor W. (2018-01-01)Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) ... -
Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication
Apergis-Schoute, Annemieke M.; van der Flier, Febe E.; Ip, Samantha H.Y.; Kanen, Jonathan W.; Vaghi, Matilde M.; Fineberg, Naomi A.; Sahakian, Barbara J.; Cardinal, Rudolf N; Robbins, Trevor W. (2024-01-16)Background The nature of cognitive flexibility deficits in obsessive-compulsive disorder (OCD), which historically have been tested with probabilistic reversal learning tasks, remains elusive. Here, a novel deterministic ... -
The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study
Fernandez-Egea, Emilio; Chen, Shanquan; Sangüesa, Estela; Gassó, Patricia; Biria, Marjan; Plaistow, James; Jarratt-Barnham, Isaac; Segarra, Nuria; Mas, Sergi; Ribate, Maria-Pilar; García, Cristina B.; Fineberg, Naomi A.; Worbe, Yulia; Cardinal, Rudolf N.; Robbins, Trevor W. (2024-04-23)BackgroundA significant proportion of people with clozapine-treated schizophrenia develop ‘checking’ compulsions, a phenomenon yet to be understood.AimsTo use habit formation models developed in cognitive neuroscience to ... -
Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder : Evidence From Resting-State Functional Connectivity
Vaghi, Matilde M.; Vértes, Petra E.; Kitzbichler, Manfred G.; Apergis-Schoute, Annemieke M.; van der Flier, Febe E.; Fineberg, Naomi; Sule, Akeem; Zaman, Rashid; Voon, Valerie; Kundu, Prantik; Bullmore, Edward T.; Robbins, Trevor W. (2017-04-15)Background A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and ...