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Browsing by Author "Smith, Paul J."
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Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions
Malkinson, John P.; Zloh, Mire; Kadom, Mohanad; Errington, Rachel J.; Smith, Paul J.; Searcey, Mark (2003)The first solid-phase synthesis of the chlorofusin peptide is described. The synthesis involved side-chain immobilization of N(alpha)-Fmoc-Asp-ODmab. Synthesis of the linear peptide, initially incorporating racemic Ade8 ... -
Spectral analysis of the DNA targeting bisalkylaminoanthraquinone DRAQ5 in intact living cells
Njoh, Kerenza L.; Patterson, Laurence H.; Zloh, Mire; Wiltshire, Marie; Fisher, Janet; Chappell, Sally; Ameer-Beg, Simon; Bai, Yanhong; Matthews, Daniel; Errington, Rachel J.; Smith, Paul J. (2006-08)We report on the potential DNA binding modes and spectral characteristics of the cell-permeant far red fluorescent DNA dye, DRAQ5, in solution and bound within intact cells. Our aim was to determine the constraints for its ...