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    • SB-334867-A antagonises orexin mediated excitation in the locus coeruleus 

      Soffin, E.M.; Evans, M.L.; Gill, C.H.; Harries, M.; Benham, C.D.; Davies, C.H. (2002)
      Electrophysiological recordings from identified noradrenergic locus coeruleus (LC) neurones in rat brain slices have revealed that the orexins can cause direct and reversible depolarisation of the postsynaptic membrane. ...