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Browsing by Author "Spinthakis, Nikolaos"
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Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation
Spinthakis, Nikolaos; Gue, Ying X.; Farag, Mohamed; Srinivasan, Manivannan; Wellsted, David; Lip, Gregory Y H; Arachchillage, Deepa RJ; Gorog, Diana (2019-09-01)AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants ... -
Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction- a substudy of the CONDI-2/ERIC4 PPCI randomised controlled trial
Gorog, Diana; Farag, Mohamed; Spinthakis, Nikolaos; Yellon, Derek M.; Bøtker†, Hans E; Kharbanda, Rajesh; Hausenloy, Derek (2020-03-12)Background: Remote ischaemic conditioning (RIC) has been shown to reduce myocardial infarct size in animal models of myocardial infarction. Platelet thrombus formation is a critical determinant of outcome in ST-segment ... -
Impact of Preadmission Morphine on Reinfarction in Patients With ST-Elevation Myocardial Infarction Treated With Percutaneous Coronary Intervention : A Meta-Analysis
Gue, Ying; Spinthakis, Nikolaos; Farag, Mohamed; Kubica, Jacek; Siller-Matula, Jolanta M; Srinivasan, Manivannan; Gorog, Diana (2020-01-28)Opiates are the traditional analgesics used in patients with ST-elevation myocardial infarction (STEMI). Pharmacodynamic studies indicate that opiates delay the absorption of orally administered P2Y 12 inhibitors and the ... -
Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture
Spinthakis, Nikolaos; Gue, Ying; Farag, Mohamed; Ren, Guogang; Srinivasan, Manivannan; Baydoun, Anwar; Gorog, Diana A (2019-04-01)Impaired endogenous fibrinolysis is an adverse prognostic biomarker in acute coronary syndrome (ACS). Abnormally dense in vitro fibrin thrombi have been demonstrated in ACS patients and related to hypofibrinolysis using ... -
Impaired endogenous fibrinolysis in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events : the RISK PPCI study
Farag, Mohamed; Spinthakis, Nikolaos; Gue, Ying X.; Srinivasan, Manivannan; Sullivan, Keith; Wellsted, David; Gorog, Diana A. (2019-01-14)Aims: The endogenous fibrinolytic system serves to prevent lasting thrombotic occlusion and infarction following initiation of coronary thrombosis. We aimed to determine whether impaired endogenous fibrinolysis can identify ... -
Is there a role for oral triple therapy in patients with acute coronary syndromes without atrial fibrillation?
Spinthakis, Nikolaos; Farag, Mohamed; Akhtar, Zaki; Gorog, Diana Adrienne (2018)BACKGROUND: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term. METHODS: Here we review ... -
More, More, More: Reducing Thrombosis in Acute Coronary Syndromes Beyond Dual Antiplatelet Therapy-Current Data and Future Directions.
Spinthakis, Nikolaos; Farag, Mohamed; Rocca, Bianca; Gorog, Diana (2018-02-06)Common to the pathogenesis of acute coronary syndromes (ACS) is the formation of arterial thrombus, which results from platelet activation and triggering of the coagulation cascade.1 To attenuate the risk of future thrombotic ... -
Morphine Analgesia Pre-PPCI Is Associated with Prothrombotic State, Reduced Spontaneous Reperfusion and Greater Infarct Size
Farag, Mohamed; Spinthakis, Nikolaos; Srinivasan, Manivannan; Sullivan, Keith; Wellsted, David; Gorog, Diana A (2018-03-01)The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, ... -
Non-Vitamin K Antagonist Oral Anticoagulants versus Warfarin for Patients with Left Ventricular Thrombus: A Systematic Review and Meta-analysis
Gue, Ying X.; Spinthakis, Nikolaos; Egred, Mohaned; Gorog, Diana; Farag, Mohamed (2021-03-01) -
Percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting : A meta-analysis of patients with left main coronary artery disease
Spinthakis, Nikolaos; Farag, Mohamed; Gorog, Diana A; Prasad, Abhiram; Mahmood, Hamid; Gue, Ying; Wellsted, David; Nabhan, Ashraf; Srinivasan, Manivannan (2017-12-15)BACKGROUND: The relative efficacy and safety of percutaneous coronary intervention (PCI) with drug-eluting stents (DES), in comparison to coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) ... -
Precision treatment in ACS – role of assessing fibrinolysis
Gue, Ying X.; Jeong, Young-Hoon; Farag, Mohamed; Spinthakis, Nikolaos; Gorog, Diana (2021-03-01)Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, ... -
Spontaneous Coronary Artery Dissection : The Phantom Menace
Spinthakis, Nikolaos; Abdulkareem, Nada; Farag, Mohamed; Gorog, Diana A (2016-12-01)We present a case of a 66-year-old lady with chest pain, without dynamic 12-lead electrocardiographic (ECG) changes and normal serial troponin. Coronary angiography revealed a linear filing defect in the first obtuse ... -
Spontaneous reperfusion in patients with transient ST-elevation myocardial infarction - prevalence, importance and approaches to management
Farag, Mohamed; Peverelli, Marta; Spinthakis, Nikolaos; Gue, Ying X.; Egred, Mohaned; Gorog, Diana (2021-07-10)Patients with transient ST-elevation myocardial infarction (STEMI) or spontaneous resolution (SpR) of the ST-segment elevation on electrocardiogram could potentially represent a unique group of patients posing a therapeutic ... -
Thrombotic Profile and Oral Anticoagulation in Asian and Non-Asian Patients With Nonvalvular Atrial Fibrillation
Gue, Ying X.; Inoue, Nobutaka; Spinthakis, Nikolaos; Takahara, Hiroyuki; Otsui, Kazunori; Lip, Gregory Y H; Gorog, Diana (2019-12-03) -
Use of bioresorbable vascular scaffold : a meta-analysis of patients with coronary artery disease
Farag, Mohamed; Spinthakis, Nikolaos; Gorog, Diana A; Prasad, Abhiram; Sullivan, Keith; Akhtar, Zaki; Kukreja, Neville; Srinivasan, Manivannan (2016-08-26)BACKGROUND: Differences in outcomes between bioresorbable vascular scaffold (BVS) systems and drug-eluting metal stents (DES) have not been fully evaluated. We aimed to compare clinical and angiographic outcomes in randomised ...