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Targeting glycolysis : a fragment based approach towards bifunctional inhibitors of hLDH-5
Moorhouse, Adam D.; Spiteri, Christian; Sharma, Pallavi; Zloh, Mire; Moses, John E. (2011)hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.