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Browsing by Author "Teo, I."
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Computational design principles for bioactive dendrimer based constructs as antagonists of the TLR4-MD-2-LPS complex
Barata, T.; Teo, I.; Lalwani, S.; Simanek, E.; Zloh, Mire; Shaunak, S. (2011-11-01)The cell surface interaction between bacterial lipopolysaccharide (LPS), Toll-like receptor 4 (TLR4) and MD-2 is central to bacterial sepsis syndromes and wound healing. We have shown that a generation (G) 3.5 polyamidoamine ... -
Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses
Barata, T.S.; Brocchini, S.; Teo, I.; Zloh, Mire; Shaunak, S. (2011-06-01)The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide ... -
Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers
Teo, I.; Toms, S.M.; Marteyn, B.; Barata, T.S.; Simpson, P.; Johnston, K.A.; Schnupf, P.; Puhar, A.; Bell, T.; Tang, C.; Zloh, Mire; Matthews, S.; Rendle, P.M.; Sansonetti, P.J.; Shaunak, S. (2012-09-01)Intestinal pathogens use the host's excessive inflammatory cytokine response, designed to eliminate dangerous bacteria, to disrupt epithelial gut wall integrity and promote their tissue invasion. We sought to develop a ... -
Site-specific PEGylation of protein bisulfide bonds using a three-carbon bridge
Balan, S.; Godwin, A.; Laborde, C.M.; Brocchini, S.; Choi, J.-W.; Teo, I.; Shaunak, S.; Heidelberger, S.; Zloh, Mire (2007)The covalent conjugation of a functionalized poly(ethylene glycol) (PEG) to multiple nucleophilic amine residues results in a heterogeneous mixture of PEG positional isomers. Their physicochemical, biological, and ... -
Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers
Barata, T.S.; Teo, I.; Shaunak, S.; Zloh, Mire; Brocchini, S. (2011-08-01)The partial modification of carboxylic acid terminated polyamidoamine (PAMAM) dendrimers with glucosamine has been reported to give dendrimer glucosamine conjugates novel immuno-modulatory and anti-angiogenic properties. ...