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Browsing by Author "Thakur, Shori"
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2-oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis
Patel, Jessal; Bourne, Lucie E; Thakur, Shori; Farrington, Kenneth; Gorog, Diana; Orriss, Isabel R; Baydoun, Anwar (2020-09-12)Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ... -
Diabetes confers in vitro calcific potential on serum which associates with in-vivo vascular calcification
Patidar, Ashish; Singh, Dhruv; Thakur, Shori; Winocour, Peter; Farrington, Kenneth; Baydoun, Anwar (2017-05-09)Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum, enabling it to induce ... -
The Impact of Semicarbazide Sensitive Amine Oxidase Activity on Rat Aortic Vascular Smooth Muscle Cells
Manasieva, Vesna; Thakur, Shori; Lione, Lisa A.; Baydoun, Anwar R.; Skamarauskas, John (2023-03-03)Semicarbazide-sensitive amine oxidase (SSAO) is both a soluble- and membrane-bound transmembrane protein expressed in the vascular endothelial and in smooth muscle cells. In vascular endothelial cells, SSAO contributes to ... -
Post-transcriptional divergence in the regulation of CAT-2A, CAT-2B and iNOS expression by dexamethasone in vascular smooth muscle cells
Thakur, Shori; Baydoun, A. R. (2012)Upregulation of l-arginine transport by pro-inflammatory mediators is a widely reported phenomenon which accompanies the expression of the inducible nitric oxide synthase (iNOS) enzyme in various cells. Both processes ... -
Uremic serum-induced calcification of human aortic smooth muscle cells is a regulated process involving Klotho and RUNX2
Patidar, Ashish; Singh, Dhruv K; Thakur, Shori; Farrington, Ken; Baydoun, Anwar R (2019-10-11)Vascular calcification (VC) is common in subjects with chronic kidney disease (CKD) and is associated with increased cardiovascular risk. It is an active process involving transdifferentiation of arterial smooth muscle ...