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Browsing by Author "Thomas, S. R."
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H-1 NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists
Herbert, R. H.; Gerhard, U.; Mortishire-Smith, R. J.; Thomas, S. R.; Hollingworth, G. (2005-08)The binding affinities at the human NK-1 receptor of two spirocyclic compounds were found to be similar despite being epimeric at a key stereocentre. This unexpected result prompted a thorough investigation of the solution ... -
Open-access high-resolution mass spectrometry in early drug discovery
Thomas, S. R.; Gerhard, Ute (2004-08)Techniques such as mass spectrometry and NMR spectroscopy form an essential part of the medicinal chemist's toolbox for characterizing and assessing the purity of new molecules. Empowering medicinal chemists to gain early ...