Browsing by Author "Tiberghien, Arnaud C"

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    • Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents 

      Antonow, Dyeison; Kaliszczak, Maciej; Kang, Gyoung-Dong; Coffils, Marissa; Tiberghien, Arnaud C; Cooper, Nectaroula; Barata, Teresa; Heidelberger, Sibylle; James, Colin H; Zloh, Mire; Jenkins, Terence C; Reszka, Anthony P; Neidle, Stephen; Guichard, Sylvie M; Jodrell, Duncan I; Hartley, John A; Howard, Philip W; Thurston, David E (2010)
      A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding ...