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Browsing by Author "Torben-Nielsen, Ben"
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Centrosomin represses dendrite branching by orienting microtubule nucleation
Yalgin, Cagri; Ebrahimi, Saman; Delandre, Caroline; Yoong, Li Foong; Akimoto, Saori; Tran, Heidi; Amikura, Reiko; Spokony, Rebecca; Torben-Nielsen, Ben; White, Kevin P.; Moore, Adrian W. (2015-10-01)Neuronal dendrite branching is fundamental for building nervous systems. Branch formation is genetically encoded by transcriptional programs to create dendrite arbor morphological diversity for complex neuronal functions. ... -
Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses
Sudhakar, Shyam Kumar; Torben-Nielsen, Ben; De Schutter, Erik (2015-12-02)Neurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. ... -
A comparison of methods to determine neuronal phase-response curves
Torben-Nielsen, Ben; Uusisaari, Marylka; Stiefel, Klaus M. (2010)The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both ... -
The Computing Dendrite : From Structure to Function
Remme, Michiel W.H.; Cuntz, Hermann; Torben-Nielsen, Ben; School of Computer Science (Springer Nature, 2014) -
Context-aware modeling of neuronal morphologies
Torben-Nielsen, Ben; De Schutter, Erik (2014)NEURONAL MORPHOLOGIES ARE PIVOTAL FOR BRAIN FUNCTIONING: physical overlap between dendrites and axons constrain the circuit topology, and the precise shape and composition of dendrites determine the integration of inputs ... -
Directional hearing in a silicon cricket
Reeve, Richard; van Schaik, André; Jin, Craig; Hamilton, Tara; Torben-Nielsen, Ben; Webb, Barbara (2007-02)Phonotaxis is the ability to orient towards or away from sound sources. Crickets can locate conspecifics by phonotaxis to the calling (mating) song they produce, and can evade bats by negative phonotaxis from echolocation ... -
An efficient and extendable python library to analyze neuronal morphologies
Torben-Nielsen, Ben (2014-10) -
Evolution of Dendritic Morphologies Using Deterministic and Nondeterministic Genotype to Phenotype Mapping
Alva, Parimala; De Sousa, Giseli; Torben-Nielsen, Ben; Maex, Reinoud; Adams, Roderick; Davey, N.; Steuber, Volker (Springer Nature, 2013)In this study, two morphological representations in the genotype, a deterministic and a nondeterministic representation, are compared when evolving a neuronal morphology for a pattern recognition task. The deterministic ... -
The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations
Torben-Nielsen, Ben; Segev, Idan; Yarom, Yosef (2012)It is commonly accepted that the Inferior Olive (IO) provides a timing signal to the cerebellum. Stable subthreshold oscillations in the IO can facilitate accurate timing by phase-locking spikes to the peaks of the ... -
The Green's function formalism as a bridge between single- and multi-compartmental modeling
Wybo, Willem A. M.; Stiefel, Klaus M.; Torben-Nielsen, Ben (2013-12)Neurons are spatially extended structures that receive and process inputs on their dendrites. It is generally accepted that neuronal computations arise from the active integration of synaptic inputs along a dendrite between ... -
Input-location dependent gain modulation in cerebellar nucleus neurons
Psarrou, Maria; Schilstra, Maria; Davey, Neil; Torben-Nielsen, Ben; Steuber, Volker (2016-08-18) -
An inverse approach for elucidating dendritic function
Torben-Nielsen, Ben; Stiefel, Klaus M. (2010)We outline an inverse approach for investigating dendritic function-structure relationships by optimizing dendritic trees for a priori chosen computational functions. The inverse approach can be applied in two different ... -
Oscillatory activity, phase differences, and phase resetting in the inferior olivary nucleus
Lefler, Yaara; Torben-Nielsen, Ben; Yarom, Yosef (2013)The generation of temporal patterns is one of the most fascinating functions of the brain. Unlike the response to external stimuli temporal patterns are generated within the system and recalled for a specific use. To ... -
Proposed evolutionary changes in the role of myelin
Stiefel, Klaus M; Torben-Nielsen, Ben; Coggan, Jay S (2013)Myelin is the multi-layered lipid sheet periodically wrapped around neuronal axons. It is most frequently found in vertebrates. Myelin allows for saltatory action potential (AP) conduction along axons. During this form of ... -
Self-referential forces are sufficient to explain different dendritic morphologies
Memelli, Heraldo; Torben-Nielsen, Ben; Kozloski, James (2013)Dendritic morphology constrains brain activity, as it determines first which neuronal circuits are possible and second which dendritic computations can be performed over a neuron's inputs. It is known that a range of ... -
A Sparse Reformulation of the Green's Function Formalism Allows Efficient Simulations of Morphological Neuron Models
Wybo, Willem A. M.; Boccalini, Daniele; Torben-Nielsen, Ben; Gewaltig, Marc-Oliver (2015-12)We prove that when a class of partial differential equations, generalized from the cable equation, is defined on tree graphs and the inputs are restricted to a spatially discrete, well chosen set of points, the Green's ... -
Spatially distributed dendritic resonance selectively filters synaptic input
Laudanski, Jonathan; Torben-Nielsen, Ben; Segev, Idan; Shamma, Shihab (2014-08)An important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, ... -
Synaptic plasticity and pattern recognition in cerebellar Purkinje cells
De Sousa, Giseli; Maex, Reinoud; Adams, Roderick; Davey, N.; Steuber, Volker (Springer Nature, 2014)Many theories of cerebellar learning assume that long-term depression (LTD) of synapses between parallel fibres (PFs) and Purkinje cells is the basis for pattern recognition in the cerebellum. Here we describe a series of ... -
Systematic mapping between dendritic function and structure
Torben-Nielsen, Ben; Stiefel, Klaus M. (2009)For many classes of neurons, the relationship between computational function and dendritic morphology remains unclear. To gain insights into this relationship, we utilize an inverse approach in which we optimize model ... -
Wide-field motion integration in fly VS cells : insights from an inverse approach
Torben-Nielsen, Ben; Stiefel, Klaus M. (2010)Fly lobula plate tangential cells are known to perform wide-field motion integration. It is assumed that the shape of these neurons, and in particular the shape of the subclass of VS cells, is responsible for this type of ...