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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)
Uguru, Gabriel C; Mondhe, Madhav; Goh, Shan; Hesketh, Andrew; Bibb, Mervyn J; Good, Liam; Stach, James E M (2013-06-27)We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic ...