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Browsing by Author "Vaghi, Matilde M."
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Compulsivity Reveals a Novel Dissociation between Action and Confidence
Vaghi, Matilde M.; Luyckx, Fabrice; Sule, Akeem; Fineberg, Naomi A.; Robbins, Trevor W.; De Martino, Benedetto (2017-10-11)Confidence and actions are normally tightly interwoven—if I am sure that it is going to rain, I will take an umbrella—therefore, it is difficult to understand their interplay. Stimulated by the ego-dystonic nature of ... -
Hypoactivation and Dysconnectivity of a Frontostriatal Circuit During Goal-Directed Planning as an Endophenotype for Obsessive-Compulsive Disorder
Vaghi, Matilde M.; Hampshire, Adam; Kaser, Muzaffer; Fineberg, Naomi; Brühl, Annette B.; Sahakian, Barbara J.; Chamberlain, Samuel R.; Robbins, Trevor W. (2017-11-01)Background The symptoms of obsessive-compulsive disorder (OCD) have been postulated to result from impaired executive functioning and excessive habit formation at the expense of goal-directed control and have been objectively ... -
Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders : Cognitive Domains, Neural Circuitry, and Treatment
Fineberg, Naomi A.; Apergis-Schoute, Annemieke M.; Vaghi, Matilde M.; Banca, Paula; Gillan, Claire M.; Voon, Valerie; Chamberlain, Samuel R.; Cinosi, Eduardo; Reid, Jemma; Shahper, Sonia; Bullmore, Edward T.; Sahakian, Barbara J.; Robbins, Trevor W. (2018-01-01)Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) ... -
Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication
Apergis-Schoute, Annemieke M.; van der Flier, Febe E.; Ip, Samantha H.Y.; Kanen, Jonathan W.; Vaghi, Matilde M.; Fineberg, Naomi A.; Sahakian, Barbara J.; Cardinal, Rudolf N; Robbins, Trevor W. (2024-01-16)Background The nature of cognitive flexibility deficits in obsessive-compulsive disorder (OCD), which historically have been tested with probabilistic reversal learning tasks, remains elusive. Here, a novel deterministic ... -
Set-shifting related basal ganglia deformation as a novel familial marker of obsessive-compulsive disorder
Isobe, Masanori; Vaghi, Matilde M.; Fineberg, Naomi; Apergis-Schoute, Annemieke M.; Bullmore, Edward T.; Sahakian, Barbara J.; Robbins, Trevor; Chamberlain, Samuel R. (2021-04-21)The symptoms of obsessive-compulsive disorder (OCD) are suggestive of cognitive rigidity, and previous work identified impaired flexible responding on set-shifting tasks in such patients. The basal ganglia are central to ... -
Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder : Evidence From Resting-State Functional Connectivity
Vaghi, Matilde M.; Vértes, Petra E.; Kitzbichler, Manfred G.; Apergis-Schoute, Annemieke M.; van der Flier, Febe E.; Fineberg, Naomi; Sule, Akeem; Zaman, Rashid; Voon, Valerie; Kundu, Prantik; Bullmore, Edward T.; Robbins, Trevor W. (2017-04-15)Background A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and ...