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Browsing by Author "Valentin, Jean-Pierre"
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Translational potential of a mouse in-vitro bioassay in predicting gastrointestinal adverse drug reactions in phase 1 clinical trials
Keating, Christopher; Ewart, Lorna; Grundy, Luke; Valentin, Jean-Pierre; Grundy, David (2014-07)Background: Motility-related gastrointestinal adverse drug reactions (GADRs) such as diarrhoea and constipation are a common and deleterious feature associated with drug development. Novel biomarkers of GI function are ... -
The validation of an invitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions
Keating, Christopher; Ewart, Lornal; Gibbons, Stephen; Grundy, Luke; Valentin, Jean-Pierre; Grundy, David (2010-06)Motility-related gastrointestinal adverse drug reactions (GADRs), such as constipation and diarrhea, are some of the most frequently reported adverse events associated with the clinical development of new chemical entities, ...