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Browsing by Author "Warner, T.D."
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COX-1, and not COX-2 activity, regulates airway function : Relevance to aspirin-sensitive asthma
Harrington, L.S.; Lucas, R.; McMaster, S.K.; Moreno, L.; Scadding, G.; Mitchell, J.A.; Warner, T.D. (2008-11-01)Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 ... -
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Kirkby, N.S.; Lundberg, M.H.; Harrington, L.S.; Leadbeater, P.D.M.; Potter, C.M.F.; Al-Yamani, M.; Adeyemi, O.; Mitchell, J.A.; Warner, T.D.; Milne, G.L. (2012-10-23)Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production ... -
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Kirkby, N.S.; Zaiss, A.K.; Urquhart, P.; Jiao, J.; Austin, P.J.; Al-Yamani, Malak; Lundberg, M.H.; MacKenzie, Louise; Warner, T.D.; Nicolaou, A.; Herschman, H.R.; Mitchell, J.A. (2013-07-09)There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ... -
Making anti-thrombotic bypass vessels from selected populations of vascular smooth muscle cells
Dhanji, A.A.; Ali, F.Y.; MacKenzie, Louise Susan; Shipolini, A.; Mitchell, J.A.; Warner, T.D. (2010-06)Objectives: Vein grafts are commonly used for coronary artery bypass surgery but poor long-term patency and high failure rate make the idea of ‘designer’ bypass vessels attractive. Here we have investigated the possibility ... -
Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells : Comparison with Toll-like receptor 4 responses in macrophages
Moreno, L.; McMaster, S.K.; Gatheral, T.; Bailey, L.; Harrington, L.; Cartwright, N.; Armstrong, P.C.J.; Warner, T.D.; Paul-Clark, M.; Mitchell, J.A. (2010-08)Background and purpose: Gram-negative bacteria contain ligands for Toll-like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors. Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products ... -
Role of COX-1 and COX-2 in the release of prostanoids in murine lung and isolated lung fibroblasts
Wright, William; Kirkby, Nick; MacKenzie, Louise Susan; Lundberg, Martina; Paul-Clark, M.J.; Warner, T.D. (2011-06)Cyclooxygenase (COX) is the first enzyme in the conversion of arachidonic acid to prostanoids. There are two isoforms of COX; COX-1, which is constitutively expressed with a homeostatic role in most tissues, and COX-2, ... -
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms
Potter, C.M.F.; Lundberg, M.H.; Harrington, L.S.; Moshkov, A.V.; Gorelik, J.; Mitchell, J.A.; Warboys, C.M.; Weinberg, P.D.; Warner, T.D.; Berson, R.E. (2011-02)Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2. Methods and ... -
Role of the endothelium and COX-1 in prostacyclin generation by whole vessels stimulated with different agonists
Alyamanil, Malak; Kirkby, N.S.; MacKenzie, Louise Susan; Lundberg, M.H.; Warner, T.D.; Mitchell, J.A. (2012)Prostacyclin is an important cardioprotective hormone produced by the vascular wall, whose synthesis is dependent on cyclo-oxygenase (COX) enzymes. In healthy vessels the endothelium is thought to be the main site of ...