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Browsing by Author "White, John R."
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Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B
Berkhout, Theo; Sarau, Henry M.; Moores, Kitty E.; White, John R.; Elshourbagy, Nabil; Appelbaum, Edward; Reape, Theresa J.; Brawner, Mary; Makwana, Jayneeta; Foley, James J.; Schmidt, Dulcie B.; Imburgia, Christine; McNulty, Dean; Matthews, Jane; O'Donnell, Kevin; O'Shannessy, Daniel; Scott, Miller; Groot, Pieter H E; Macphee, Colin H. (1997-06-27)Here we describe the characterization of a novel human CC chemokine, tentatively named monocyte chemotactic protein (MCP-4). This chemokine was detected by random sequencing of expressed sequence tags in cDNA libraries. ... -
Identification of a truncated form of the CC chemokine CKβ-8 demonstrating greatly enhanced biological activity
MacPhee, Colin H.; Appelbaum, Edward R.; Johanson, Kyung; Moores, Kitty E.; Imburgia, Christina S.; Fornwald, Jim; Berkhout, Theo; Brawner, Mary; Groot, Pieter H. E.; O'Donnell, Kevin; O'Shannessy, Daniel; Scott, Gil; White, John R. (1998-12-01)A new CC chemokine, designated CKβ-8 or myeloid progenitor inhibitor factor-1, was recently identified in a large scale sequencing effort and was cloned from a human aortic endothelial library. CKβ-8 cDNA encodes a signal ... -
Novel chemokine receptor inhibition assay
School of Life and Medical Sciences; Department of Pharmacy; Health & Human Sciences Research Institute; Medicinal and Analytical Chemistry; Berkhout, Theo; Groot, P. H. E.; Elshourbagy, Nabil; Bergsma, Derek; White, John R. (1998)Ligands MCP-4, MCP-3, RANTES, MCP-2, MCP-1 or eotaxin, has been identified for the G-protein receptor HGBER32. -
Selective binding of the truncated form of the chemokine CKβ8 (25-99) to CC chemokine receptor 1 (CCR1)
Berkhout, Theo; Gohil, Jayneeta; Gonzalez, Pilar; Nicols, Charlotte L.; Moores, Kitty E.; MacPhee, Colin H.; White, John R.; Groot, Pieter H. E. (2000-03-01)Human CC chemokine receptor 1 (CCR1) has been proposed as a receptor for CKβ8. To obtain conclusive evidence, binding-displacement studies of 125I-CKβ8 (25-99) were performed on membranes of Chinese hamster ovary cells ...