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Browsing by Author "Whitfield, P.J."
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A comparison of topical formulations for the prevention of human schistosomiasis
Cooper, E.; Iqbal, A.; Bartlett, A.; Marriott, C.; Whitfield, P.J.; Brown, Marc (2004-08)Recently, a dimeticone formulation has been shown to be effective at preventing Schistosoma cercariae infecting skin, while DEET (N,N-diethyl-m-toluamide), a highly effective insecticide, has been shown to have activity ... -
Demethylation of 2,4-dimethoxquinolines: the synthesis of atanine
Jones, K.; Roset, X.; Rossiter, S.; Whitfield, P.J. (2003) -
Dimethicone barrier cream prevents infection of human skin by Schistosome cercariae : Evidence from Franz cell studies
Ingram, R.J.; Bartlett, A.; Marriott, C.; Whitfield, P.J.; Brown, Marc (2002-04)One approach to the prevention of schistosomiasis is the use of topical formulations to inhibit cercalial penetration of skin. A number of formulations containing either cercaricidal ingredients or components designed to ... -
The effect of unsaturated fatty acids in benzyl alcohol on the percutaneous permeation of three model penetrants
Nanayakkara, G.R.; Bartlett, A.; Forbes, B; Marriott, C.; Whitfield, P.J.; Brown, Marc (2005-09-14)The model penetrants butyl paraben (BP), methyl paraben (MP) and caffeine (CF), because of their different octanol/water partition coefficients and postulated routes of permeation through human skin, were selected to assess ... -
Immunomodulatory effects of schistosome cercarial interactions with human keratinocytes and Langerhans cells
Nanayakkar, G. R.; Bartlett, A.; Whitfield, P.J.; Brown, Marc; Groves, R. W. (2007-05)The human parasite Schistosoma mansoni is known to modulate host immune responses in order to promote its own survival. However, studies investigating the interaction between the skin-invading cercarial stage and cells of ... -
The infection of human skin by schistosome cercariae : studies using Franz cells
Bartlett, A.; Brown, Marc; Marriott, C.; Whitfield, P.J. (2000)Franz cells (2-chambered, air fluid phase static diffusion devices, previously used for the study of drugs across viable human skin) are utilized for the first time to investigate the process of infection of human skin by ... -
Penetration of human skin by the cercariae of Schistosoma mansoni : an investigation of the effect of multiple cercarial applications
Ingram, R.J.; Bartlett, A; Brown, Marc; Marriott, C.; Whitfield, P.J. (2003)It has previously been postulated that L-arginine emitted by penetrating Schistosoma mansoni cercariae serves as an intraspecific signal guiding other cercariae to the penetration site. It was suggested that penetrating ... -
Schistosome cercarial interactions with human keratinocytes and langerhans cells
Nanayakkara, G.R.; Bartlett, A.; Whitfield, P.J.; Brown, Marc; Groves, R. (2006-08)The human parasite, Schistosoma mansoni is known to modulate host immune responses in order to promote its own survival. However, studies investigating the interaction between the skin-invading cercarial stage and cells ... -
Skin invasion by schistosome cercariae : insights gained from studies with human skin explants
Whitfield, P.J.; Bartlett, A.; Brown, M.P.; Marriott, C. (2003) -
Synthesis and anthelmintic properties of arylquinolines with activity against drug resistant nematodes
Rossiter, S.; Peron, J. M.; Whitfield, P.J.; Jones, K. (2005)