- UHRA Home
- Browsing by Author
Browsing by Author "Williams, Robert J."
Now showing items 1-4 of 4
-
Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
Vauzour, David; Vafeiadou, Katerina; Rice-Evans, Catherine; Williams, Robert J.; Spencer, Jeremy P. E. (2007-11)There is growing interest in the potential beneficial effects of flavonoids in the aging and diseased brain. We have investigated the potential of the flavanone hesperetin and two of its metabolites, hesperetin-7-O-beta- ... -
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
Vafeiadou, Katerina; Vauzour, David; Lee, Hung Yi; Rodriguez-Mateos, Ana; Williams, Robert J.; Spencer, Jeremy P. E. (2009-04-01)Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) ... -
Glial metabolism of quercetin reduces its neurotoxic potential
Vafeiadou, Katerina; Vauzour, David; Rodriguez-Mateos, Ana; Whiteman, Matthew; Williams, Robert J.; Spencer, Jeremy P. E. (2008-10-15)The neuroprotective effects of flavonoids will ultimately depend on their interaction with both neuronal and glial cells. In this study, we show that the potential neurotoxic effects of quercetin are modified by glial cell ... -
Neuroinflammation : modulation by flavonoids and mechanisms of action
Spencer, Jeremy P. E.; Vafeiadou, Katerina; Williams, Robert J.; Vauzour, David (2012-02)Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease. Recently, there has ...