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Browsing by Author "Yang, Zhuo"
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Attenuated effect of tungsten carbide nanoparticles on voltage-gated sodium current of hippocampal CA1 pyramidal neurons
Shan, Dehong; Xie, Yongling; Ren, Guogang; Yang, Zhuo (2013-02)Nanomaterials and relevant products are now being widely used in the world, and their safety becomes a great concern for the general public. Tungsten carbide nanoparticles (nano-WC) are widely used in metallurgy, aeronautics ... -
AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats
Li, Junyang; Liu, Meicen; Gao, Jin; Jiang, Yu; Wu, Limin; Cheong, Yuen-Ki; Ren, Guogang; Yang, Zhuo (2020-07-01)Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients ... -
Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway
Gao, Jing; Zhang, Xiaochen; Yu, Mei; Ren, Guogang; Yang, Zhuo (2015-11-04)Multi-walled carbon nanotubes (MWCNTs) have shown potential applications in many fields, especially in the field of biomedicine. Several studies have reported that MWCNTs induce apoptosis and oxidative damage in nerve cells ... -
Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors
Xie, Yongling; Wang, Yiyi; Zhang, Tao; Ren, Guogang; Yang, Zhuo (2012-02-03)Background: Nanomaterials, as a new kind of materials, have been greatly applied in different fields due to their special properties. With the industrialization of nanostructured materials and increasing public exposure, ... -
Etidronate rescues cognitive deficits through improving synaptic transmission and suppressing apoptosis in 2-vessel occlusion model rats
Li, Wen; Yuan, Huijuan; Yu, Yao; Cheong, Yuen-Ki; Ren, Guogang; Yang, Zhuo (2017-01-20)Vascular dementia (VD) is a neurodegenerative disorder caused by the reduction of cerebral blood flow. It shows a progressive cognitive impairment. In our previous study, we found that etidronate (ET) showed neuroprotective ... -
In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells
Han, Yang-guang; Xu, Jing; Li, Zhi-gui; Ren, Guogang; Yang, Zhuo (2012-10)The present study aimed to evaluate the potential toxicity and the general mechanism involved in multi-walled carbon nanotubes (MWCNT)-induced cytotoxicity in C6 rat glioma cell line. Two kinds of MWCNT, which were coded ... -
In vitro toxicity of nanosized copper particles in PC12 cells induced by oxidative stress
Xu, Pengjuan; Xu, Jing; Liu, Shichang; Ren, Guogang; Yang, Zhuo (2012-06)Recent evidence suggests that some nanomaterials, which are widely used in many fields, have health effects. In order to investigate the cytotoxicity induced by nanosized copper particles (nano-Cu), PC12 cells, which were ... -
Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons
Shan, Dehong; Xie, Yongling; Ren, Guogang; Yang, Zhuo (2012-03-07)The effects of tungsten carbide nanoparticles (nano-WC) on the properties of voltage-dependent potassium currents and evoked action potentials were studied in the hippocampal CA1 pyramidal neurons of rats at the ages of ... -
The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons
Liu, Zhaowei; Ren, Guogang; Zhang, Tao; Yang, Zhuo (2011-10)The application of the nano-sized materials continues to grow at a rapid rate in the fields of medicine, biotechnology, and environmental technology. Voltage-gated potassium currents play a key role in excitable cellular ... -
Involvement of reactive oxygen species and high-voltage-activated calcium currents in nanoparticle zinc oxide-induced cytotoxicity in vitro
Zhao, Jingxia; Yao, Yang; Liu, Shichang; Zhang, Tao; Ren, Guogang; Yang, Zhuo (2012-11)This study was to determine the possible neurotoxicity and mechanisms underlying the effects of nano-ZnO with sizes of 20-80 nm on central nervous system (CNS). The cytotoxicity of nano-ZnO was investigated in PC12 cells. ... -
Multi-walled carbon nanotube increases the excitability of hippocampal CA1 neurons through inhibition of potassium channels in rat’s brain slices
Chen, Ting; Yang, Jiajia; Ren, Guogang; Yang, Zhuo; Zhang, Tao (2013-02-27)This study was to investigate the neurotoxicity of multi-walled carbon nanotube (MWCNT) by measuring neuronal excitability in rat hippocampal neurons and exploring the underlying mechanism. Whole cell patch-clamp technique ... -
Multi-walled carbon nanotube inhibits CA1 glutamatergic synaptic transmission in rat's hippocampal slices
Chen, Ting; Yang, Jiajia; Zhang, Hui; Ren, Guogang; Yang, Zhuo; Zhang, Tao (2014-09-17)The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp ... -
Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons
Liu, Zhaowei; Zhang, Tao; Ren, Guogang; Yang, Zhuo (2012-06)The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The ... -
Neuroprotective Effects of Etidronate and 2,3,3-Trisphosphonate Against Glutamate-Induced Toxicity in PC12 Cells
Li, Wen; Cheong, Yuen-Ki; Wang, Hui; Ren, Guogang; Yang, Zhuo (2016-04-01)Etidronate is one of the best known bisphosphonates (BP) derivatives. It is often used as a reference drug in research related to hypercalcaemia and other common bone diseases. 2,3,3-trisphosphonate (TrisPP) is brand new ...