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dc.contributor.authorBucci, M.
dc.contributor.authorVellecco, V.
dc.contributor.authorBrancaleone, V.
dc.contributor.authorRoviezzo, F.
dc.contributor.authorMattace Raso, G.
dc.contributor.authorIanaro, A.
dc.contributor.authorMeli, R.
dc.contributor.authorCirino, G.
dc.contributor.authorHarrington, L.
dc.contributor.authorLungarella, G.
dc.contributor.authorDe Palma, R.
dc.date.accessioned2013-06-13T10:30:49Z
dc.date.available2013-06-13T10:30:49Z
dc.date.issued2013
dc.identifier.citationBucci , M , Vellecco , V , Brancaleone , V , Roviezzo , F , Mattace Raso , G , Ianaro , A , Meli , R , Cirino , G , Harrington , L , Lungarella , G & De Palma , R 2013 , ' Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function ' , British Journal of Pharmacology , vol. 168 , no. 2 , pp. 411-420 . https://doi.org/10.1111/j.1476-5381.2012.02205.x
dc.identifier.issn0007-1188
dc.identifier.otherPURE: 1746104
dc.identifier.otherPURE UUID: 781c704d-7250-48f7-9c09-9c337b0496ce
dc.identifier.otherScopus: 84871539770
dc.identifier.urihttp://hdl.handle.net/2299/10760
dc.description.abstractBackground and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models. Experimental Approach Thoracic aortas were harvested from both naïve and endotoxaemic rats for in vitro studies. Arterial blood pressure was monitored in anaesthetized rats in vivo. LPS was used as a TLR4 agonist while PAR activating peptide (AP) was used as a PAR agonist. Aortas harvested from TLR4 mice were also used to characterize the PAR response. Key Results PAR , but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PARAP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR AP-induced vasorelaxation and PARAP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4 mice, the expression of PAR was reduced and the PARAP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective. Conclusions and Implications Cross-talk between PAR and TLR4 contributes to vascular homeostasis.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofBritish Journal of Pharmacology
dc.titleCross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular functionen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionCardiovascular Pathologies
dc.contributor.institutionDiabetic neuropathies
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84871539770&partnerID=8YFLogxK
rioxxterms.versionSMUR
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1476-5381.2012.02205.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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